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DHEA increases insulin-mediated glucose disposal in hypoadrenal women.
2004 DEC 2 - (NewsRx.com & NewsRx.net) -- Mayo Clinic researchers found that dehydroepiandrosterone (DHEA) significantly increased insulin-mediated glucose disposal in a group of hypoadrenal women.
The finding led them to question the need for DHEA in this patient population.
"Dehydroepiandrosterone and its sulfated ester (DHEAS) are the most abundant circulating steroid hormones. Their physiological function has yet to be determined. Hypoadrenal subjects lack this hormone because DHEA replacement is not part of the current standard of care. There are conflicting reports on the impact of DHEA replacement in hypoadrenal subjects on insulin sensitivity," said K. Dhatariya and colleagues with the Mayo Clinic's Endocrine Research Unit in Rochester, Minnesota, U.S.
They conducted a study to study this and to "examine skeletal muscle physiology using a hyperinsulinemic euglycemic clamp after 12 weeks of DHEA and placebo" in a randomized, double-blind, placebo-controlled, crossover study.
The study group - 33 hypoadrenal women ([+ or -]SD) (mean age 49.7 [+ or -] 15.6 years) - received either DHEA 50 mg or placebo in a single daily dose.
"After 12 weeks body composition was assessed by DEXA and insulin sensitivity was assessed," according to the researchers.
They found no differences in body composition. "Fasting plasma insulin and glucagon were lower with DHEA (7.07 [+ or -] 4.35 vs. 8.88 [+ or -] 5.81 microU/ml, p=0.003; and 177.7 [+ or -] 59.9 vs. 195.04 [+ or -] 79.5 pg/ml, p=0.038, respectively)," Dhatariya's group reported.
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- Magazine article from: Alternative Medicine Review Dhatariya, K. Bigelow, M.L. Nair, K.S. June 1, 2005 700+ words
...crossover study in 28 hypoadrenal women (mean age 50...50-mg dose of DHEA daily or placebo...therapy with 50 mg of DHEA for 12 weeks significantly...insulin sensitivity in hypoadrenal women, thereby suggesting that DHEA replacement could...
- Can DHEA help prevent diabetes?(dehydroepiandrosterone)(Brief Article)
- Magazine article from: Townsend Letter for Doctors and Patients Gaby, Alan R. January 1, 2006 700+ words
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- Newspaper article from: Nutrition Action Healthletter Schardt, David Schardt, Stephen March 1, 1997 700+ words
...live longer, feel better."--The DHEA Breakthrough, by Stephen Cherniske...Dr. Julian Whitaker, as quoted on the DHEA Connection's home page (www.tucsonlink...Dr. Earl Mindell, as quoted on the DHEA Center's home page (www.dheacenter...
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- Press release article from: PR Newswire January 15, 1997 700+ words
...15 /PRNewswire/ -- One of the biggest criticisms of the new DHEA craze, is that when you take DHEA from an over-the-counter supplier, you often don't know what your DHEA levels are and how much you should REALLY be taking. Body Ammo...
- DHEA.(dehydroepiandrosterone)
- Magazine article from: Alternative Medicine Review June 1, 2001 700+ words
Introduction Dehydroepiandrosterone (DHEA) is a steroid hormone secreted primarily...physiological responses. Circulating levels of DHEA decline with age and a relationship has been suggested between lower DHEA levels and heart disease, cancer, diabetes...
- DHEA, the 'mother hormone,' may be the inner fountain to longer life
- Magazine article from: Better Nutrition Dolby, Victoria November 1, 1996 700+ words
...cumbersome name dehydroepiandrosterone, or DHEA for short, is a more promising aging antidote. Although DHEA's popularity is just recently starting...discovered over 60 years ago - in 1934. DHEA is called the "mother hormone" because...
- DHEA boosts growth rate of human neural stem cells.
- Newspaper article from: Health & Medicine Week March 8, 2004 700+ words
...exposed in a lab dish to the steroid DHEA, exhibit a remarkable uptick in growth...direct evidence of the biological effects of DHEA on the human nervous system, according...of Sciences USA. "What we saw was that DHEA significantly increased the division of...
- DHEA Replacement in Women with Adrenal Insufficiency.
- Magazine article from: OB/GYN Clinical Alert December 1, 1999 700+ words
DHEA Replacement in Women with Adrenal Insufficiency...adrenal insufficiency, the androgenic precursor DHEA improves well-being and sexuality. Source...physiological roles of dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) remain uncertain...
Source: HighBeam Research, DHEA increases insulin-mediated glucose disposal in hypoadrenal women.