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Phytoestrogens inhibit mRNA expression, aromatase activity human GL cells.
2004 DEC 2 - (NewsRx.com & NewsRx.net) -- Phytoestrogens inhibit mRNA expression and aromatase activity in human granulosa-luteal (GL) cells, preliminary study data show.
S. Rice and S.A. Whitehead, of the St. George's Hospital Medical School in London, England, reported the data at the 195th Meeting of the Society for Endocrinology, held November 1-3, 2004.
They explained, "Phytoestrogens bind weakly to estrogen receptors and can initiate estrogen-dependent transcription. They are promoted as natural alternatives to hormone replacement therapy and yet epidemiological evidence suggests that they may protect against breast and prostate cancer.
"Studies in cell-free preparations have shown that phytoestrogens can inhibit the activity of aromatase and that the inhibition is, at least partly, competitive with androgen substrates. The question as to whether chronic exposure to phytoestrogens may alter the expression of aromatase and thereby modulate the conversion of androgens to estrogens has not been addressed," Rice and Whitehead told the conference.
In their study they "investigated the effects of three isoflavones (genistein, diadzein, and biochanin A), two flavones (quercetin and apigenin), and the mycotoxin zearalenone on mRNA and protein expression of aromatase after exposure of human GL cells to these phytoestrogens for 48 hours."
"Real time reverse transcriptase-polymerase chain reaction was ...
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Source: HighBeam Research, Phytoestrogens inhibit mRNA expression, aromatase activity human GL...