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Link between HRT and hormone-dependent cancers studied in Norwegian women.

Women's Health Weekly

| December 02, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 DEC 2 - (NewsRx.com & NewsRx.net) -- Data from the Norwegian Women and Cancer (NOWAC) study indicate that hormone therapy isn't associated with increased risk of endometrial or ovarian cancer, although it is linked to breast cancer.

L. Bakken and colleagues, University of Tromso, Norway, wrote, "Increasing use of hormone replacement therapy (HRT) over the last 2 decades could have contributed to the increasing incidence of cancer in women. Our aim was to investigate the relation between use of HRT and risk of hormone-dependent cancers in a Norwegian cohort of women.

"The Norwegian Women and Cancer (NOWAC) study is a representative, national, population-based cohort study. This report includes 35,456 postmenopausal women aged 45-64 years who answered a postal questionnaire in 1996-1998 providing information on reproduction, lifestyle, and use of HRT. The women were followed up for cancer incidence," explained the researchers.

They analyzed data on 31,451 postmenopausal women for whom there was complete information.

"Ever use of HRT was reported by 43.5% and current use by 35% of the women. Current users had an increased risk of breast cancer (adjusted RR = 2.1, 95% CI 1.5-2.5). The risk increased with increasing duration of use (p-trend

"Using a regimen of continuous estrogen-progestagen implied an increased risk. Adjusted RRs associated with

"We found no significant increase in risk of ...

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