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Low-resource settings need sensitive, less expensive and sophisticated HPV test.
2004 DEC 2 - (NewsRx.com & NewsRx.net) -- Results of a study from India caused researchers to call for more sensitive and sophisticated, but less expensive, human papillomavirus testing for cervical neoplasia lesions in low-resource settings.
"The knowledge that cervical neoplasia are caused by human papillomavirus (HPV) infection has led to the evaluation of its role in screening. We evaluated the accuracy of HPV testing by Hybrid capture II (HC II) method in detecting cervical intraepithelial neoplasia grade 2 and 3 (CIN 2 and 3) lesions in four cross-sectional studies with common protocol and questionnaire in three different locations (Kolkata, Mumbai, and Trivandrum) in India," said R. Sankaranarayanan and colleagues, International Agency for Research on Cancer, Lyon, France.
"The reference standard for final diagnosis was a combination of colposcopy/biopsy," according to their study.
In this large study, 18,085 women (25-65 years old) "were investigated with colposcopy and 3,116 received directed biopsy," the researchers said.
They reported, "The sensitivity of HPV testing for detecting CIN 2-3 lesions varied from 45.7% to 80.9% across the study sites, the specificity varied from 91.7% to 94.6%, and the positive predictive value from 6.7% to 13.7%.
"Retesting of 298 randomly chosen denatured samples in France revealed an agreement rate of 85.9% and a kappa-value of 0.72."
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Source: HighBeam Research, Low-resource settings need sensitive, less expensive and...