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Centrosome-associated PIBF gene is overexpressed in highly proliferating cells.
2004 DEC 2 - (NewsRx.com & NewsRx.net) -- The progesterone-induced blocking factor (PIBF) gene is overexpressed in highly proliferating cells and also is associated with the centrosome, report Intercell AG researchers.
Based on these findings, they suggest further study to see if highly expressed PIBF in tumors is directly involved in tumorigenesis.
"PIBF was previously identified as a 34-kDa immunomodulatory molecule secreted by pregnancy lymphocytes and is thought to play a crucial role in preventing rejection of the embryo by the maternal immune response. Recent data suggested that PIBF protein was also expressed by the progesterone receptor (PR) positive MCF-7 breast tumor cell line. Therefore our study was designed to analyze the expression of PIBF in malignant cell lines and primary tumors both at the mRNA and protein levels," said M. Lachmann and colleagues, Intercell AG, Vienna, Austria.
"RNA expression analyses of several human cell lines with different tissue origin and paired human tumor/normal tissues, as well as of several PR+ and PR- breast tumors revealed that PIBF mRNA was overexpressed in highly proliferating cells independent of the presence of PR," the researchers said.
"In addition to the full-length PIBF mRNA encoding for a 90-kDa protein, several alternatively spliced species were detected, all resulting from perfect exon skipping. The most frequently identified splice variant is predicted to encode for an approximately 35-kDa protein. Immunofluorescence microscopy revealed a centrosomal localization for the ...
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- Press release article from: M2 Presswire January 24, 2009 700+ words
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Source: HighBeam Research, Centrosome-associated PIBF gene is overexpressed in highly...