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Connective tissue disorder risk in breast implant patients re-assessed.
2004 DEC 2 - (NewsRx.com & NewsRx.net) -- Scientists have re-assessed the risk of connective tissue disorders in breast implant patients.
"In a U.S. retrospective cohort study (1960-1996), 351 (4.8%) of 7,234 patients with breast implants and 62 (2.9%) of 2,138 patients who had undergone other types of plastic surgery reported subsequent rheumatoid arthritis (RA), scleroderma, systemic lupus erythematosus, or Sjogren syndrome (relative risk=2.0, 95% confidence interval (CI): 1.5, 2.8). Risks of RA, scleroderma, and Sjogren syndrome were elevated both before and after 1992, when the Food and Drug Administration changed the status of breast implants to investigational," investigators in the United States report.
"When records for these diseases were retrieved (35-40% retrieval rate) and blindly reviewed, two expert rheumatologists assessed only a minority of the cases as being 'likely' (e.g., regarding RA, 16.5% for implant patients and 23.5% for comparison patients)," stated Louise A. Brinton at the National Cancer Institute and collaborators in the U.S. "Recalculation of incidence rates using 'likely' diagnoses found relative risks of 2.5 (95% CI: 0.8, 7.8) for RA, scleroderma, and Sjogren syndrome combined and 1.9 (95% CI: 0.6, 6.2) for RA only. When the proportions deemed 'likely' were applied to all self-reports, the estimated relative risks were ...
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Source: HighBeam Research, Connective tissue disorder risk in breast implant patients...