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Tc-99m-MIBI scintimammography inappropriate for routine evaluation of lesions.
2004 DEC 2 - (NewsRx.com & NewsRx.net) -- Study results suggest Tc-99m-MIBI scintimammography is inappropriate for routine evaluation of breast microcalcifications detected by standard mammography.
Researchers in France wanted to determine if Tc-99m-MIBI scintimammography could "improve the diagnostic value of mammography for the differentiation of benign and malignant breast microcalcifications."
The radiologic imaging technique was applied to 41 women presenting 45 clusters of microcalcifications before they underwent open biopsy. Of the 45 clusters, 24 (53%) were determined to be malignant lesions by Tc-99m-MIBI scintimammography.
"The sensitivity (SE) and specificity (SP) of Tc-99m-MIBI scintimammography were 58.3% and 81%, and the positive and negative predictive values (PPV, NPV) were 78% and 63%, respectively," reported E. Fondrinier and colleagues, adding that "SE and PPV increased for lesions over 10 mm and for the younger patients (under 50 years)."
They found no correlation "between true positive uptake and breast cancer invasiveness: 69% (9/13) for invasive lesions and 45% (5/11) for noninvasive lesions (p=0.48)."
"Tc-99m-MIBI scintimammography was more often positive in high grade ...
- Tc-99m-MIBI scintimammography inappropriate for routine evaluation of lesions.
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