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Death receptor 4 kills breast cancer cells despite the absence of TRAIL.
2004 DEC 2 - (NewsRx.com & NewsRx.net) -- Death receptor 4 kills breast cancer cells despite the absence of TRAIL.
According to recent research from the United States, "breast cancer cells are generally resistant to induction of apoptosis by treatment with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). In this study, we demonstrate that both TRAIL-sensitive and TRAIL-resistant breast cancer cell lines can be efficiently killed by overexpression of the TRAIL receptor, death receptor 4 (DR4). The extent of cell death depended on the strength of the promoter driving DR4 expression."
"When driven by the strong cytomegalovirus (CMV) promoter, expression of DR4 killed over 90% of cells in 5 out of 6 cell lines tested in the absence of exogenous TRAIL," I. Kazhdan and colleagues, University of Texas, Health Science Center reported.
"When driven by the relatively weak tumor-specific hTERT promoter, DR4 was less effective alone, but sensitized cells to killing by TRAIL. The extent of TRAIL sensitization depended on the magnitude of hTERT promoter activity. MCF-7 cells were relatively resistant to the action of DR4. We compared expression of the genes involved in transduction and execution of the death ...
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Source: HighBeam Research, Death receptor 4 kills breast cancer cells despite the absence of...