AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Marginal zone B cells deposit immune complexes onto dendritic cells.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells.
According to published research from the United States, "Secreted IgM and complement are important mediators in the optimal initiation of primary T-dependent humoral immune responses. Secreted IgM serves as a natural adjuvant by enhancing the immunogenicity of protein antigens, perhaps as a result of IgM's ability to facilitate antigen deposition onto follicular dendritic cells (FDCs) and promote rapid germinal center (GC) formation. To understand how IgM enhances adaptive immune responses, we investigated the mechanism by which IgM-containing immune complexes (IgM-IC) are transported to FDCs as a first step in GC formation."
"We demonstrate that IgM-IC localize first to the splenic marginal zone (MZ) where the IgM-IC bind MZ B cells in a complement and complement receptor (CR1/2) dependent process," stated Andrew R. Ferguson and colleagues at Boston University. "MZ B cells then transport the IgM-IC into the follicle for deposition onto FDCs. Mice with reduced numbers of MZ B cells trap IgM-IC on FDC less efficiently, whereas mice with reduced numbers of follicular B cells trap IgM-IC normally. The functional elimination of MZ B cells abrogates the ability of FDCs to trap IgM-IC. Transfer of B cells with ...
- Dendritic cells tied to psoriasis.(News)
- Magazine article from: Skin & Allergy News McNamara, Damian March 1, 2006 700+ words
...FLA. -- Recent research implicates dendritic cells in the pathogenesis of psoriasis and...promise by halting cytokines produced by dendritic cells, he noted. Psoriasis is widely known...published since 2003) suggest that dendritic cells also play a role. Researchers believe...
- IL-10-treated dendritic cells may induce GVHD risk.
- Newspaper article from: Biotech Week May 5, 2004 700+ words
...amp; NewsRx.net) -- Dendritic cells treated with interleukin...IL-10-treated immature dendritic cells in the first mixed leukocyte...were cultured with mature dendritic cells of the same origin as IL...
- Dendritic cells heterogeneity and its role in cancer immunity.(Review Article)
- Magazine article from: Journal of Cancer Research and Therapeutics Kah-Wai, Lin Jacek, Tabarkiewicz Jacek, Rolinski April 1, 2006 700+ words
...Tabarkiewicz. Jacek, Rolinski. Jacek Dendritic cells are the most potent 'professional...primary immune response initiation. Dendritic cells originate from bone marrow progenitors...subsequently give rise to immature dendritic cells, which reside in peripheral tissues...
- FLT3 LIGAND STIMULATES GROWTH OF DENDRITIC CELLS
- Press release article from: PR Newswire November 30, 1995 700+ words
...been shown to promote the growth of dendritic cells, a formerly elusive type of cell...now, research into the utility of dendritic cells has been hampered because these cells...large numbers of functionally mature dendritic cells. "Dendritic cells could be quite...
- Scientists describe how dendritic cells grow up to take on foreign invaders.
- Newspaper article from: Proteomics Weekly March 24, 2003 700+ words
...Acting as the body's sentinels, dendritic cells are constantly on the lookout for...yet to be explained, only mature dendritic cells process and accumulate these threatening...fueled an interest in using activated dendritic cells to fight cancer and other diseases...
- Future psoriasis drugs may target role of dendritic cells.(Rx)
- Magazine article from: Internal Medicine News McNamara, Damian March 1, 2006 700+ words
...FLA. -- Recent research implicates dendritic cells in the pathogenesis of psoriasis and...promise by halting cytokines produced by dendritic cells, he noted. Psoriasis is widely known...been published since 2003) suggest dendritic cells also play a role by activating the...
- Decidual CD83+ dendritic cells implicated in some recurrent miscarriages.
- Magazine article from: Women's Health Weekly April 15, 2004 700+ words
...NewsRx.net) -- Decidual CD83+ dendritic cells may contribute to some cases of recurrent...Potent immunostimulatory (CD83) dendritic cells have recently been identified in the...sought to determine "whether decidual dendritic cells could play a role in the etiology...
- Bacillus anthracis Fires Arsenal Of Toxic Factors At Immune System, Leaving...
- Magazine article from: BIOWORLD Today November 4, 2009 700+ words
...fingers the shooter: "Impairment of dendritic cells and adaptive immunity by anthrax lethal...lethal factor impairs the function of dendritic cells and thereby compromises the immune...targets the immune system's pivotal dendritic cells. Their prime function is to recognize...
Source: HighBeam Research, Marginal zone B cells deposit immune complexes onto dendritic cells.