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Comprehensive screening detects new epitopes in hepatitis C virus NS3 antigen.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Comprehensive screening detects new epitopes in hepatitis C virus NS3 antigen.
"Interferon-gamma (IFN-gamma)-producing CD8+ T cells have been shown to play a key role in the control or eradication of hepatitis C virus (HCV) infections. In particular, T cells specific for the non-structural protein 3 (NS3) are often associated with control of viremia. The aim of the study was to identify novel HLA-A2 restricted CD8+ T cell epitopes specific for NS3 using a combination of comprehensive approaches," scientists writing in the Journal of Medical Virology report.
"HLA-A2.1 transgenic mice were immunized with a DNA vaccine optimized for NS3 specific epitope presentation and induced CD8+ T cell reactivity was screened using 42 algorithm-predicted peptides as well as a library of 78 overlapping 15-mer peptides spanning the whole protein," described P. Martin and colleagues, CNRS, BioMerieux.
"Three epitopes mapping within the NS3 protease (GLL: as 1038-1047) or helicase (ATL: as 1260-1268 and TLH: as 1617-1625) were identified. These epitopes, which display similar and high in vitro binding capacities to soluble HLA-A2 molecules, are able to induce either cytotoxic T lymphocytes (CTL) and/or IFN-gamma-producing T cells.
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Source: HighBeam Research, Comprehensive screening detects new epitopes in hepatitis C virus NS3...