AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
In vivo function of gamma-herpesvirus virion glycoprotein described.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Researchers describe the in vivo function of gamma-herpesvirus virion glycoprotein in a recent issue of the Journal of Virology.
According to a study from the United Kingdom, "The human gamma-herpesviruses Epstein-Barr virus and Kaposi Sarcoma-associated herpesvirus both contain a glycoprotein (gp350/220 and K8.1, respectively) that mediates binding to target cells and has been studied in great detail in vitro. However, there is no direct information on the role that these glycoproteins play in pathogenesis in vivo. Infection of mice by murid herpesvirus 4 strain 68 (MHV-68) is an established animal model for gamma-herpesvirus pathogenesis and expresses an analogous glycoprotein, gp150."
"To elucidate the in vivo function of gp150, a recombinant MHV-68 deficient in gp150 production was generated (vgp150Delta)," said James P. Stewart at the University of Liverpool and collaborators in the U.K. "The productive viral replication in vitro and in vivo was largely unaffected by mutation of gp150, aside from a partial defect in the release of extracellular virus. Likewise, B-cell latency was established. However, the transient mononucleosis and spike in latently infected cells associated with the spread of MHV-68 to the spleen was significantly reduced in vgp150Delta-infected mice."
"A soluble, recombinant gp150 was found to bind specifically to B cells but not to ...
- Kaposi sarcoma secondary to pulmonary tuberculosis: a rare case.(Case Report)
- Magazine article from: Southern Medical Journal Guler, Zuhal Mujgan Kanbay, Asiye Ciftci, Bulent Kanbay, Mehmet Yilmaz, Aydin Agackiran, Yetkin Erdogan, Yurdanur September 1, 2005 700+ words
Abstract: Kaposi sarcoma commonly occurs in HIV-positive and...immunocompromised patients. We describe a case of Kaposi sarcoma that developed in an HIV-negative patient with tuberculosis. The Kaposi sarcoma completely regressed with antituberculous...
- Wolf in sheep's clothing: advanced Kaposi sarcoma mimicking vulvar...
- Magazine article from: Southern Medical Journal Laartz, Brent W. Cooper, C.D.H. Degryse, Amber Sinnott, John T. April 1, 2005 700+ words
Abstract: Kaposi sarcoma is a vascular neoplastic disorder...AIDS). The causative factor in Kaposi sarcoma is human herpes virus-8. This...However, we present a case of Kaposi sarcoma mimicking the benign and common...
- PAX2 plays key role in Kaposi sarcoma pathogenesis.
- Newspaper article from: Drug Week March 26, 2004 700+ words
...key role in the pathogenesis of Kaposi sarcoma. In a recent study, scientists in Italy found that "Kaposi sarcoma cells but not human microvascular...on spindle-shaped cells, in Kaposi sarcoma lesions," noted S. Buttiglieri...
- Viral gene responsible for oncogenesis identified.(Kaposi sarcoma associated...
- Newspaper article from: Cancer Weekly April 1, 2003 700+ words
...responsible for initiating oncogenesis in Kaposi sarcoma has been identified - at last - by...at Weill Cornell Medical College. Kaposi sarcoma associated herpes virus (KSHV...promise for alternative treatments of Kaposi sarcoma by blocking the actions of the vGPCR...
- Studies from Johns Hopkins University reveal new findings on Kaposi sarcoma.
- Newspaper article from: Angiogenesis Weekly May 8, 2009 700+ words
"Kaposi sarcoma-associated herpesvirus (KSHV...with three distinct malignancies: Kaposi sarcoma (KS), primary effusion lymphoma...the United States report (see also Kaposi Sarcoma). "The KSHV genome has been fully...
- Viral gene responsible for oncogenesis identified.(viral G-protein coupled...
- Newspaper article from: AIDS Weekly March 31, 2003 700+ words
...responsible for initiating oncogenesis in Kaposi sarcoma has been identified - at last - by...at Weill Cornell Medical College. Kaposi sarcoma associated herpes virus (KSHV...promise for alternative treatments of Kaposi sarcoma by blocking the actions of the vGPCR...
- Kaposi sarcoma-associated herpesvirus ORF K1 mediates endothelial cell turnover.
- Newspaper article from: Cancer Weekly February 24, 2004 700+ words
...com & NewsRx.net) -- Kaposi sarcoma-associated herpesvirus ORF K1...from Sweden, "infection with Kaposi sarcoma-associated herpesvirus (KSHV) is a prerequisite for Kaposi sarcoma, a multicentric endothelial tumor...
- Kaposi sarcoma-associated herpesvirus K1 protein stimulates invasion factors.
- Newspaper article from: Cancer Weekly June 22, 2004 700+ words
...com & NewsRx.net) -- Kaposi sarcoma-associated herpesvirus K1 protein stimulates invasion factors. "Kaposi sarcoma-associated herpesvirus (KSHV/HHV-8) has been linked to Kaposi sarcoma, primary effusion lymphoma, and...
- Scientists at Lund University publish new data on Kaposi sarcoma.
- Newspaper article from: Blood Weekly February 26, 2009 700+ words
...fully sequenced homolog of human Kaposi sarcoma-associated herpesvirus. Both these...complement inhibitors as follows: Kaposi sarcoma-associated herpesvirus-complement...colleagues, Lund University (see also Kaposi Sarcoma). The researchers concluded: "This...
- Paclitaxel tops second-line choices for AIDS-related Kaposi sarcoma.(Cutaneous...
- Magazine article from: Skin & Allergy News Jancin, Bruce January 1, 2008 700+ words
...choice in patients whose AIDS-related Kaposi sarcoma isn't responsive to liposomal anthracydines...University of Vienna. For localized Kaposi sarcoma, surgery, cryotherapy, radiation...for the treatment of AIDS-related Kaposi sarcoma--are given with palliative rather...
Source: HighBeam Research, In vivo function of gamma-herpesvirus virion glycoprotein described.