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Aggresome-like structures form in herpes virus type 2-infected cells.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Aggresome-like structures form in herpes simplex virus type 2-infected cells, which play a potential role in virus assembly.
According to a study from Japan, "Herpes simplex virus (HSV) is a large, enveloped DNA virus that replicates in the nucleus and is assembled in the cytoplasm to the mature infectious virion. In this study, we present evidence that, in HSV-2-infected cells, some tegument proteins (UL46 and VP16) and newly synthesized nucleocapsids accumulate in a juxtanuclear domain sharing characteristics with aggresomes, cellular structures formed in response to misfolded proteins."
"The juxtanuclear domains (aggresome-like structures) induced by HSV-2 infection localize to the microtubule organizing center (MTOC) where the clustering mitochondria, Golgi-derived vesicles, and cellular chaperones including heat shock protein (Hsp)40 and Hsp70 were recruited," stated Naoki Nozawa and collaborators at Nagoya University and Chubu University. "Formation of aggresome-like structures was blocked by the presence of microtubule-disassembling drug nocodazole, indicating that microtubule-dependent transport may be involved in the accumulation of viral and cellular proteins at these sites in HSV-2-infected cells. These features are similar to those governing the formation of aggresomes."
"In contrast to aggresomes, however, the vimentin cage surrounding the MTOC was ...
- Cytotoxic T cells inactivated by HSV-infected cells.
- Newspaper article from: Biotech Week April 28, 2004 700+ words
...by herpes simplex virus (HSV)-infected cells expressing a viral protein...cell contact between CTL and HSV-infected cells. However, inactivated CTL...the CTL are removed from the HSV-infected cells. "IL-2 treatment does...
- UL51 is localized in virion linked with viral envelopment in HSV-infected cells.
- Newspaper article from: Virus Weekly April 15, 2003 700+ words
...with viral envelopment in HSV-infected cells. "The herpes simplex virus...of 27, 29, and 30 kDa in HSV-1-infected cells. "In this study, we have...with viral envelopment in HSV-infected cells." Nozawa and colleagues...
- Virus expressing HSV-2 glycoproteins protects against HSV-2 challenge.
- Newspaper article from: Immunotherapy Weekly September 8, 2004 700+ words
...recombinant Oka VZV infected cells; recombinant Oka VZV expressing HSV-2 gB/gD (ROka-gB2/gD2) infected cells; or heat-inactivated ROka-gB2/gD2 infected cells. Only animals inoculated...neutralizing antibodies to HSV-2." "Animals...
- Herpesvirus CJ83193 is effective vaccine against HSV-1 infection.
- Newspaper article from: Health & Medicine Week August 9, 2004 700+ words
...a novel replication-defective and anti-HSV-specific HSV-1 recombinant, CJ83193. The UL9-C535C...as well as the replication of wild-type HSV-1 and RSV-2 in co-infected cells." "In this report, we demonstrate that...
- HSV-1 LATs Suppress IE Genes During Primary Infection
- Newspaper article from: Gene Therapy Weekly July 13, 1998 700+ words
...influence upon expression of HSV-1 immediate-early (IE...Our findings indicate that HSV-1 LATs suppress viral replication...mRNA levels, the LATs may keep HSV-1 replication lower than levels...increased numbers of 1) latently infected cells with a LAT-positive virus...
- HSV-1 caps viral protein and increases cellular spread in response to IgG.
- Newspaper article from: Anti-Infectives Week February 24, 2003 700+ words
...also enhance cell to cell spread of wild type HSV-1 but not of gE deletion mutant HSV-1." Rizvi and coauthors concluded...dependent mechanisms exist that allow some HSV-1 infected cells to respond to the presence of extracellular...
- HSV-1 caps viral protein and increases cellular spread in response to...
- Newspaper article from: Virus Weekly February 25, 2003 700+ words
...also enhance cell to cell spread of wild type HSV-1 but not of gE deletion mutant HSV-1." Rizvi and coauthors concluded...dependent mechanisms exist that allow some HSV-1 infected cells to respond to the presence of extracellular...
- HSV-1 Us3 protein kinase blocks apoptosis induced by Bcl-2 expression.
- Newspaper article from: Health & Medicine Week May 10, 2004 700+ words
...amp; NewsRx.net) -- The HSV-1 Us3 protein kinase is sufficient...herpes simplex virus type-1 (HSV-1) suppresses apoptosis in infected cells and is sufficient to block apoptosis...their study in Virology (The HSV-1 Us3 protein kinase is sufficient...