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Outbreak of hepatitis B in drug users causes high mortality.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- An outbreak of acute hepatitis B among injection drug users caused fulminant liver failure resulting in high mortality.
"Death related to acute hepatitis B occurs in approximately 1% of patients. We investigated an outbreak of hepatitis B virus (HBV) infections among injection drug users (IDUs) resulting in several deaths. We conducted a case-control study of fulminant (case patients) and nonfulminant (control patients) HBV infections. We directly sequenced the entire HBV genome from fulminant and nonfulminant cases. From October 1998 to July 2000, 21 acute HBV infections, including 10 fulminant hepatitis B cases, were identified," scientists writing in the journal Hepatology report.
"The median age was 30 (range, 18-49) years, 12 (57%) were female, 20 (95%) were American Indians, and 20 (95%) reported injecting illicit drugs," stated Richard S. Garfein at the Centers for Disease Control and Prevention and collaborators in the U.S. "All patients with fulminant hepatitis B died (case-fatality rate=47.6%). Case patients (n=5) and control patients (n=9) were similar with respect to age, sex, race, and hepatitis C virus serostatus. All case patients used acetaminophen during their illness compared with 44% of control patients (p=0.08)."
"Compared with control patients, case patients lost more weight in the six months before illness (p=0.04); during their illness, they used more alcohol (p=0.03) and methamphetamine ...
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