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Autoimmune encephalomyelitis cured by Trypanosoma cruzi infection.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Experimental autoimmune encephalomyelitis can be prevented and cured by infection with Trypanosoma cruzi.
"Trypanosoma cruzi is an intracellular parasite that induces a strong Th1-type response and immunosuppression during the acute phase of infection. To study how the infection with T. cruzi would modulate the development of an autoimmune disease, we immunized C57BL/6 mice and IL-10 or iNOS knock-out mice of the same background with the encephalitogenic MOG 35-55 peptide and infected them with T. cruzi," researchers in Brazil report.
"Our results demonstrate that infection with T. cruzi completely prevents EAE development and furthermore induces complete and lasting remission in mice that were infected with this parasite after they had developed clinical EAE," said Carlos E. Tadokoro at the University of Sao Paulo and collaborators in Brazil. "Nitric oxide and IL-10 participate in triggering the mechanisms associated with EAE suppression by the infection. Decreased lymphoproliferation and increased frequencies of Annexin-positive cells and of T cells bearing CD95, CD95L or CTLA-4 were observed in the spleen from immunized/infected mice, as well as lower IL-2 and increased TGF-beta production in comparison with only immunized mice."
The researchers ...
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