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Persistent itching nodules caused by diphtheria-tetanus toxoid vaccines.

Vaccine Weekly

| December 01, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Researchers report persistent itching nodules after the fourth dose of diphtheria-tetanus toxoid vaccines without evidence of delayed hypersensitivity to aluminum.

"Studies in Gothenburg, Sweden, reported an exceptionally high rate of persistent itching nodules at the site of injection of aluminum containing vaccines, usually with positive epicutaneous tests to aluminum. When a new booster diphtheria-tetanus vaccine was introduced we performed a prospective cluster randomized active surveillance in 25,232 10-year-olds. Parental reports six months after vaccination with Duplex or diTeBooster were collected for 22,365 (88%) pupils in 851 schools," scientists in Sweden report.

"We identified 3 to 6 children per 10,000 with a local itching nodule persisting for at least two months," said Eva Netterlid and colleagues at University Hospital in Malmo and the Swedish Institute for Infectious Disease Control. "There were no significant differences between the vaccine groups. Contact allergy to aluminum was not detected. The findings support the use of the vaccine presently ...

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Source: HighBeam Research, Persistent itching nodules caused by diphtheria-tetanus toxoid...

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