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DNA vaccine protects against lethal canine distemper virus challenge.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Immunization with plasmid DNA encoding the hemagglutinin and the nucleoprotein confers robust protection against a lethal canine distemper virus challenge.
According to recent research from Denmark and France, "We have investigated the protective effect of immunization of a highly susceptible natural host of canine distemper virus (CDV) with DNA plasmids encoding the viral nucleoprotein (N) and hemagglutinin (H). The combined intradermal and intramuscular routes of immunization elicited high virus-neutralizing serum antibody titers in mink (Mustela vison). To mimic natural exposure, we also conducted challenge infection by horizontal transmission from infected contact animals."
"Other groups received a lethal challenge infection by administration to the mucosae of the respiratory tract and into the muscle," said Lotte Dahl and collaborators at the Royal Veterinary and Agricultural University in Denmark and INSERM U404 in France. "One of the mink vaccinated with N plasmid alone developed severe disease after challenge. In contrast, vaccination with the H plasmid together with the N plasmid conferred solid protection against disease and we were unable to detect CDV infection in PBMCs or in different tissues after challenge."
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...community from the recent outbreak of canine distemper that has affected several areas...County Animal Services is offering free canine distemper vaccinations to dogs at least seven...first-come, first-serve basis. Canine Distemper is a highly contagious and serious...
