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Lipid-core-peptides increase adjuvant activity of T cell peptides.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Incorporation into lipid-core-peptides increased the adjuvant activity of minimal CD8 T cell peptides.
"A problem facing the use of subunit peptide and protein vaccines is their inability to stimulate protective immune responses. Many different approaches have been utilized to overcome this inefficient immune activation. The approach we have taken is to modify the vaccine antigen so that it now has adjuvant properties. To do this, multiple copies of minimal CD8 T cell epitopes were attached to a polylysine lipid core. These constructs are known as lipid-core-peptides (LCP)," scientists in New Zealand and Australia report.
"The research presented here examines the adjuvant activity of LCP," said Karen White and collaborators at the University of Otago in New Zealand and the University of Queensland in Australia. "Using mouse models, we were able to show that LCP were indeed able to activate antigen-presenting cells in vitro and to activate cytotoxic T-cell ...
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Source: HighBeam Research, Lipid-core-peptides increase adjuvant activity of T cell peptides.