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Cancer vaccines must break immune tolerance to malignant cells.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Cancer vaccine development involves breaking immune tolerance to malignant cells.
"Exploiting a naturally occurring defense system, the immunotherapeutic approach embodies an ideal nontoxic treatment for cancer. Despite the evidence that immune effectors can play a significant role in controlling tumor growth either in natural conditions or in response to therapeutic manipulation, the cascade of molecular events leading to tumor rejection by the immune system remains to be fully elucidated. Nevertheless, some recent tumor immunology advancements might drastically change the way to design the next generation of cancer vaccines, hopefully improving the effectiveness of this therapeutic approach," investigators in Italy report.
"In the present work, we will focus on three main areas of particular interest for the development of novel vaccination strategies: cellular or molecular mechanisms of immune tolerance to malignant cells; synergism between innate and adaptive immune response; and tumor-immune system ...
- Tunable 'nanoshells' eradicate breast malignant cells in mice.
- Newspaper article from: Medical Device Daily December 15, 2003 700+ words
Tunable nanoshells eradicate breast malignant cells in mice By DAVID LEFF Medical Device Daily Science Editor...for therapy as well as for the optical identification of malignant cells or tissue. Nanoshells, Halas continued, are metalo...
- How Genes' Behavior Affects Malignant Cells.(Brief Article)
- Magazine article from: USA Today (Magazine) February 1, 2001 700+ words
...thousands of genes do and why their behavior changes in malignant cells. Using the so-called DNA chip, they can study tens of...and a gene called asparagine synthetase (AS). Certain malignant cells lack this gene and are therefore more sensitive to the drug...
- Scientists may have found new way to fight cancer by blocking substance that...
- Newspaper article from: Knight Ridder/Tribune News Service Boyd, Robert S. April 11, 1994 700+ words
...way to fight cancer by blocking a substance that allows malignant cells to multiply wildly in the human body. The finding is only...aging process of a cell. They found traces of telomerase in malignant cells _ but not in normal cells _ of 151 women dying from cancer...
- AntiHIV agent active against malignant cells.(Brief Article)
- Newspaper article from: Cancer Weekly November 26, 2002 700+ words
...IkappaBalpha by the 26s proteasome." The HIV protease inhibitor saquinavir also blocks human proteasome activity, making malignant cells susceptible to apoptotic processes, Pajonk and coauthors found. The researchers examined prostate cancer cell lysates...
- AntiHIV agent active against malignant cells.
- Newspaper article from: Drug Week November 29, 2002 700+ words
...IkappaBalpha by the 26s proteasome." The HIV protease inhibitor saquinavir also blocks human proteasome activity, making malignant cells susceptible to apoptotic processes, Pajonk and coauthors found. The researchers examined prostate cancer cell lysates...
- AntiHIV agent active against malignant cells.(saquinavir)
- Newspaper article from: AIDS Weekly November 25, 2002 700+ words
...IkappaBalpha by the 26s proteasome." The HIV protease inhibitor saquinavir also blocks human proteasome activity, making malignant cells susceptible to apoptotic processes, Pajonk and coauthors found. The researchers examined prostate cancer cell lysates...
- Intracellular Synthesis of Telomeric Repeat Appears Lethal To Malignant Cells.
- Press release article from: Business Wire January 19, 1999 700+ words
...oligonucleotide sequence in HeLa cells. As expected, intracellular expression of the (TTAGGG)n oligo appeared to select against malignant cells which expressed the telomeric repeat whereas HeLa cultures transfected to express a control sequence of the same length...
- Infinitesimal Nano-Bullets Cook Mouse Cancers Gold-Coated Hollow Silica-Glass...
- Magazine article from: BIOWORLD Today Leff, David N. December 2, 2003 700+ words
...developed cell- and tissue-specific nanoshells that can be used for therapy as well as for the optical identification of malignant cells or tissue. "Nanoshells," Halas explained, "are metalo-dielectric nanoparticles, only slightly larger than molecules...
Source: HighBeam Research, Cancer vaccines must break immune tolerance to malignant cells.