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Virus-induced auto-antibody responses characterized.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Scientists have characterized virus-induced auto-antibody responses.
"Here we present a comprehensive molecular mapping of virus-induced autoimmune B cell responses obtained by serological identification of antigens by recombinant expression cloning analysis. Immunoscreening of cDNA expression libraries of various organs (lung, liver, and spleen) using sera from mice infected with cytopathic (vaccinia virus [VV]) or noncytopathic (lymphocytic choriomeningitis virus [LCMV]) viruses revealed a broad specificity of the elicited auto-antibody response. Interestingly, the majority of the identified auto-antigens have been previously described as auto-antigens in humans," scientists in Switzerland and Germany report.
"We found that induction of virus-induced auto-antibodies of the immunoglobulin G class largely depends on the CD40-CD40L-mediated interaction between T and B cells," stated Burkhard Ludewig at the Kantonsspital St. Gallen in Switzerland and collaborators in Switzerland and Germany. "Furthermore, antibody titers against a number of auto-antigens were comparable to the concomitantly induced antiviral ...
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Source: HighBeam Research, Virus-induced auto-antibody responses characterized.