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Plasmid DNA vaccine protects against aerosolized anthrax spores.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- A cationic lipid-formulated plasmid DNA vaccine confers sustained antibody-mediated protection against aerosolized anthrax spores.
According to a study from the United States, "DNA vaccines provide an attractive technology platform against bioterrorism agents due to their safety record in humans and ease of construction, testing, and manufacture. We have designed monovalent and bivalent anthrax plasmid DNA (pDNA) vaccines encoding genetically detoxified protective antigen (PA) and lethal factor (LF) proteins and tested their immunogenicity and ability to protect rabbits from an aerosolized inhalation spore challenge. Immune responses after two or three injections of cationic lipid-formulated PA, PA plus LF, or LF pDNAs were at least equivalent to two doses of anthrax vaccine adsorbed (AVA)."
"High titers of anti-PA, anti-LF, and neutralizing antibody to lethal toxin (Letx) were achieved in all rabbits," said Gary Hermanson at Vical Inc. and collaborators in the U.S. "Eight or nine animals in each group were challenged with 100x LD[subscript]50 of aerosolized anthrax spores 5 or 9 weeks after vaccination. An additional 10 animals vaccinated with PA pDNA were challenged >7 months postvaccination. All animals receiving PA or PA plus LF pDNA vaccines were protected. In addition, five of nine animals receiving LF pDNA survived, and the time to death was significantly delayed in the others."
"Groups receiving three immunizations with PA or PA plus ...
- DNA vaccine provides long-term protection.(cytomegalovirus)(Brief Article)
- Newspaper article from: Vaccine Weekly Greer, Michael May 8, 2002 700+ words
...NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States say that an enhanced DNA vaccine against cytomegalovirus (CMV) offers long-term protection from viral proliferation. "We previously...
- DNA vaccine provides long-term protection.
- Newspaper article from: TB & Outbreaks Week May 7, 2002 700+ words
...NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States say that an enhanced DNA vaccine against cytomegalovirus (CMV) offers long-term protection from viral proliferation. "We previously...
- DNA vaccine provides long-term protection.(Brief Article)
- Newspaper article from: Virus Weekly May 7, 2002 700+ words
...NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States say that an enhanced DNA vaccine against cytomegalovirus (CMV) offers long-term protection from viral proliferation. "We previously...
- DNA vaccine targeting HPV type 16 oncoprotein E6 developed.
- Newspaper article from: Life Science Weekly October 19, 2004 700+ words
...Scientists have developed a DNA vaccine targeting human papillomavirus...lesions, we developed a DNA vaccine encoding CRT linked...researchers in the United States report. "Our results...indicated that the CRT/E6 DNA vaccine, but not a wild-type...
- Plasmid DNA vaccine protects against aerosolized anthrax spores.
- Newspaper article from: Pharma Business Week November 29, 2004 700+ words
...formulated plasmid DNA vaccine confers sustained...study from the United States, "DNA vaccines...Sciences of the United States of America (A...formulated plasmid DNA vaccine confers sustained...Sciences of the United States of America can...Development, ...
- gag-based DNA vaccine effective in primates.
- Newspaper article from: AIDS Weekly September 30, 2002 700+ words
...medical writer - An HIV DNA vaccine can produce sustained...researchers in the United States report. Michael J...coauthors tested plasmid DNA vaccine based on codon-optimized...A gag-based HIV DNA vaccine was effective in a primate...
- gag-based DNA vaccine effective in primates.(Brief Article)
- Newspaper article from: Vaccine Weekly October 2, 2002 700+ words
...medical writer - An HIV DNA vaccine can produce sustained...researchers in the United States report. Michael J...coauthors tested plasmid DNA vaccine based on codon-optimized...A gag-based HIV DNA vaccine was effective in a primate...
- Vical Introduces RapidResponse(TM) DNA Vaccine Cell-Free Platform Designed to...
- Press release article from: PR Newswire June 4, 2007 700+ words
...RapidResponse(TM) DNA vaccine platform will include...comparison against plasmid DNA vaccine, and scale-up in...holds patents in the United States and in other key regions...RapidResponse(TM) DNA vaccine platform may be applicable...
