AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Complications of Alzheimer vaccination in nonhuman primates modeled.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Scientists have modeled hemorrhagic and encephalitic complications of Alzheimer amyloid-beta vaccination in nonhuman primates.
"The potential of amyloid-beta (A-beta) immunization as a disease-modifying therapy for Alzheimer disease is limited by the occurrence of encephalitic side effects in a subset of treated patients. The encephalitis was not predicted from immunization studies in transgenic, A-beta-depositing mice. More recently, studies in these same mice indicate that passive immunization with certain anti-A-beta antibodies can induce microhemorrhage," scientists writing in the journal Current Opinion in Immunology report.
"Cerebral amyloid angiopathy (CAA) may play a key role in determining the risk for these complications," said Sam Gandy at Thomas Jefferson University and Lary Walker at Emory University. "Because aged nonhuman primates (NHPs) have a more human-like immune system than rodents, and because NHPs naturally develop senile plaques and CAA with age, NHPs appear to be important, adjunctive models for assessing the efficacy and safety of immunotherapeutics for Alzheimer disease. Conversely, the ...
- Exposure to nonhuman primates in rural Cameroon.(Research)
- Magazine article from: Emerging Infectious Diseases Wolfe, Nathan D. Prosser, A. Tassy Carr, Jean K. Tamoufe, Ubald Mpoudi-Ngole, Eitel Torimiro, J. Ndongo LeBreton, Matthew McCutchan, Francine E. Birx, Deborah L. Burke, Donald S. December 1, 2004 700+ words
Exposure to nonhuman primates has led to the emergence of...determine the extent of exposure to nonhuman primates, persons were examined in 17...had substantial exposure to nonhuman primates, higher rates of exposure were...
- Evaluation in nonhuman primates of vaccines against Ebola virus. (Perspectives).
- Magazine article from: Emerging Infectious Diseases Geisbert, Thomas W. Pushko, Peter Anderson, Kevin Smith, Jonathan Davis, Kelly J. Jahrling, Peter B. May 1, 2002 700+ words
...90% of cases in both humans and nonhuman primates. No vaccines or treatments are available...use. We evaluated the effects in nonhuman primates of vaccine strategies that had protected...strategies successfully protected nonhuman primates from robust challenge with EBOV...
- Forest fragmentation as cause of bacterial transmission among nonhuman...
- Magazine article from: Emerging Infectious Diseases Goldberg, Tony L. Gillespie, Thomas R. Rwego, Innocent B. Estoff, Elizabeth L. Chapman, Colin A. September 1, 2008 700+ words
...bacterial transmission among humans, nonhuman primates (primates hereafter), and livestock...Infectious diseases transmitted among wild nonhuman primates, humans, and domestic animals pose...animals have shared habitats with nonhuman primates (primates hereafter) for centuries...
- Yerkes plays vital role in study challenging prevailing view of AIDS in...
- Newspaper article from: NewsRx Health August 9, 2009 700+ words
...AIDS virus infections in African nonhuman primates. SIVs are found exclusively in African...scientists believed all African nonhuman primates naturally infected with SIVs, including...suited to conduct AIDS research in nonhuman primates because it has large breeding colonies...
- Virus in nonhuman primates: zoonosis, anthroponosis and biodiversity/Virus en...
- Magazine article from: Interciencia Pujol, Flor H. June 1, 2006 700+ words
SUMMARY Nonhuman primates can harbour pathogens that might infect humans through zoonotic...infecting New World primates. The study of viral infection in nonhuman primates is important for preserving biodiversity as well as to prevent...
- Simian T-lymphotropic virus diversity among nonhuman primates,...
- Magazine article from: Emerging Infectious Diseases Sintasath, David M. Wolfe, Nathan D. LeBreton, Matthew Jia, Hongwei Garcia, Albert D. Diffo, Joseph Le Doux Tamoufe, Ubald Carr, Jean K. Folks, Thomas M. Mpoudi-Ngole, Eitel Burke, Donald S. Heneine, Walid Switzer, William M. February 1, 2009 700+ words
...T-cell lymphotropic virus (STLV) transmission from nonhuman primates to hunters, we examined 170 hunter-collected dried blood...reported in a person in Cameroon known to have been exposed to nonhuman primates (NHPs) (7). A simian counterpart of this virus has...
- Serial doses of aerosolized viral vector do well in nonhuman primates.
- Newspaper article from: Health & Medicine Week February 2, 2004 700+ words
...Serial doses of aerosolized viral vector do well in nonhuman primates. According to recent research published in the journal...repeated aerosolized doses of rAAV2 in immunocompetent nonhuman primates without associated inflammatory responses prohibitive to...
- U.S., Canadian scientists create Lassa fever vaccine for nonhuman primates.
- Newspaper article from: Frederick News-Post (Frederick, MD) June 28, 2005 700+ words
...has developed a vaccine against Lassa fever that protects nonhuman primates from experimental infection with lethal doses of Lassa...the first vaccine platform shown to completely protect nonhuman primates from Lassa virus," Dr. Geisbert said. "We are hopeful...
