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Beta-sheet breaker peptide prevents Alzheimer's memory impairments.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- A beta-sheet breaker peptide prevents A-beta-induced spatial memory impairments with partial reduction of amyloid deposits.
"Current evidence supports the notion that beta-amyloid deposits or A-beta intermediates may be responsible for the pathogenesis in Alzheimer disease (AD) patients. In the present work, we have assessed the neuroprotective effect of the chronic intraperitoneal administration of a five-amino- acid beta-sheet breaker peptide (iA-beta5p) on the rat behavioral deficit induced by the intrahippocampal A-beta-fibrils injection. At one month after the injection, animals showed a partial reduction of the amyloid deposits formed and a decreased astrocytic response around the injection site," investigators in Chile report.
"More importantly, we report that following the iA-beta5p treatment, hippocampal-dependent spatial learning paradigms, including the standard Morris water maze and a working memory analysis, showed a significant prevention from impairments induced by A-beta deposits in the dorsal hippocampus," stated Marcelo A. Chacon and colleagues at the Pontificia Universidad Catolica de Chile. "Thus, it is possible that a ...
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Source: HighBeam Research, Beta-sheet breaker peptide prevents Alzheimer's memory impairments.