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nef-deleted SHIV protects against pathogenic virus infection.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- A nef-deleted simian and human immunodeficiency virus (SHIV) protected against pathogenic virus infection.
According to published research from Japan, "To clarify the involvement of primitive non-specific immune responses in the protective effects of a live, attenuated virus, two rhesus macaques were intravenously immunized with an attenuated chimeric simian and human immunodeficiency virus (SHIV) in which the nef gene was deleted (SHIV-NI) or a SHIV having human IFN-gamma inserted into the deleted nef region (SHIV IFN-gamma). These immunized monkeys were intravenously challenged with a heterologous pathogenic SHIV (SHIV-C2/1) at four weeks post immunization (wpi)."
"After vaccination, each SHIV-NI- or SHIV IFN-gamma-immunized monkey showed a low level of SIV Gag-specific lymphocyte proliferative response but did not have neutralizing antibodies to both the parental and challenge viruses," said Yoshimi Enose at Kyoto University and collaborators in Japan. "After the challenge, the plasma viral RNA loads of the challenge virus were suppressed in all the immunized monkeys and the severe CD4+ T cell loss observed in the nonimmunized monkeys was not found."
"Thus, both SHIV IFN-gamma and SHIV-NI infections could ...
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Source: HighBeam Research, nef-deleted SHIV protects against pathogenic virus infection.