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Pseudoviruses encoding gag induces HIV gag-specific mucosal immunity.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Oral immunization with papillomavirus pseudoviruses encoding gag induced HIV-1 gag-specific mucosal immunity.
"Mucosal surfaces are the primary portals for human immunodeficiency virus (HIV) transmission. Because systemic immunization, in general, does not induce effective mucosal immune responses, a mucosal HIV vaccine is urgently needed. For this study, we developed papillomavirus pseudoviruses that express HIV-1 Gag. The pseudoviruses are synthetic, nonreplicating viruses, yet they can produce antigens for a long time in the immune system," investigators in the United States report.
"Here we show that oral immunization of mice by the use of papillomavirus pseudoviruses encoding Gag generated mucosal and systemic Gag-specific cytotoxic T lymphocytes that effectively lysed Gag-expressing target cells," said Hongtao Zhang and colleagues at Loyola University. "Furthermore, the pseudoviruses generated Gag-specific gamma interferon-producing T cells and serum immunoglobulin G (IgG) and mucosal IgA. In contrast, oral immunization with plasmid DNA encoding HIV-1 Gag did not induce specific immune responses."
"Importantly, oral immunization with the pseudoviruses induced ...
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Source: HighBeam Research, Pseudoviruses encoding gag induces HIV gag-specific mucosal immunity.