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Inflammatory stimuli increase neutrophil binding of HIV.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Activation by inflammatory stimuli increases neutrophil binding of human immunodeficiency virus type 1 and subsequent infection of lymphocytes.
According to recent research from the United States, "Resting neutrophils bind human immunodeficiency virus type I (HIV-1) and efficiently transfer infection to lymphocytes. The present study shows that a brief activation by inflammatory stimuli increases the neutrophil binding levels of both R5 and X4 isolates of HIV-1 at least two-fold. The binding occurs independently of CD4, gp120, and incubation temperature and is observed with HIV-1 propagated either in lymphocytes or in HEK293 cells."
"Significantly, HIV-1 bound to the activated neutrophils accelerates the infection of activated lymphocytes compared to free HIV-1 or to HIV-1 bound to resting neutrophils," reported Ali M. Gabali and colleagues at Rush University. "It is proposed that these events may contribute to the increased risk of HIV-1 transmission ...
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Source: HighBeam Research, Inflammatory stimuli increase neutrophil binding of HIV.