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HIV-1 Tat vaccine protects against SHIV89.6P replication in monkeys.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- HIV-1 Tat vaccinated cynomolgus monkeys were protected against SHIV89.6P replication.
According to a study from Italy, "Vaccination with a biologically active Tat protein or tat DNA contained infection with the highly pathogenic SHIV89.6P virus, preventing CD4 T-cell decline and disease onset. Here we show that protection was prolonged, since neither CD4 T-cell decline nor active virus replication was observed in all vaccinated animals that controlled virus replication up to week 104 after the challenge. In contrast, virus persisted and replicated in peripheral blood mononuclear cells and lymph nodes of infected animals, two of which died."
"Tat-specific antibody, CD4 and CD8 T-cell responses were high and stable only in the animals controlling the infection," said Maria Teresa Maggiorella at the Istituto Superiore di Sanita in Rome and collaborators in Italy and the Netherlands. "In contrast, Gag-specific antibody production and CD4 and CD8 T-cell responses were consistently and persistently positive only in the monkeys that did not control primary virus replication."
Maggiorella and her associates concluded, ...
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Source: HighBeam Research, HIV-1 Tat vaccine protects against SHIV89.6P replication in monkeys.