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HIV-1 Tat protein modulates generation of cytotoxic T cell epitopes.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- HIV-1 Tat protein modulates the generation of cytotoxic T cell epitopes by modifying proteasome composition and enzymatic activity.
According to a study from Italy, "Tat, the trans activation protein of HIV, is produced early upon infection to promote and expand HIV replication and transmission. However, Tat appears to also have effects on target cells, which may affect antigen recognition both during infection and after vaccination. In particular, Tat targets dendritic cells and induces their maturation and antigen-presenting functions, increasing Th1 T cell responses. We show in this work that Tat modifies the catalytic subunit composition of immunoproteasomes in B and T cells either expressing Tat or treated with exogenous biological active Tat protein."
"In particular, Tat up-regulates latent membrane protein 7 and multicatalytic endopeptidase complex like-1 subunits and down-modulates the latent membrane protein 2 subunit," reported Riccardo Gavioli and collaborators at the University of Ferrara and the Istituto Superiore di Sanita. "These changes correlate with the increase of all three major proteolytic activities of the proteasome and result in a more efficient generation and presentation of subdominant ...
- HIV-1 Tat protein modulates generation of cytotoxic T cell epitopes.
- Newspaper article from: Obesity, Fitness & Wellness Week December 4, 2004 700+ words
...NewsRx.net) -- HIV-1 Tat protein modulates the generation of cytotoxic...exogenous biological active Tat protein." "In particular, Tat up...Journal of Immunology (HIV-1 Tat protein modulates the generation of cytotoxic...
- Hepatitis C virus NS5A protein modulates host tumor necrosis factor signals.
- Newspaper article from: Genomics & Genetics Weekly October 3, 2003 700+ words
...net) -- Hepatitis C virus NS5A protein modulates host tumor necrosis factor signals...These results indicate that HCV NS5A protein modulates TNF signaling of the host cells and...Chemistry (1 Hepatitis C virus NS5A protein modulates c-Jun N-terminal kinase through...
- Dietary protein modulates effect of CLA on lipid metabolism in rats.
- Newspaper article from: Biotech Week May 19, 2004 700+ words
...19 - (NewsRx.com & NewsRx.net) -- Dietary protein modulates the effect of conjugated linoleic acid (CLA) on lipid...associates published their findings in Lipids (Dietary protein modulates the effect of CLA on lipid metabolism in rats. Lipids...
- HCV core protein modulates immune response against HBV surface antigen.
- Newspaper article from: Drug Week December 12, 2003 700+ words
...com & NewsRx.net) -- The hepatitis C virus core protein modulates the immune response against the hepatitis B virus surface...Biochemical and Biophysical Research Communications (HCV core protein modulates the immune response against the HBV surface antigen in...
- Rubella virus capsid protein modulates virus infectivity.
- Newspaper article from: Virus Weekly June 15, 2004 700+ words
...com & NewsRx.net) -- The rubella virus capsid protein modulates viral genome replication and virus infectivity. According...study in the Journal of Virology (Rubella virus capsid protein modulates viral genome replication and virus infectivity. J Virol...
- Cleavage of amyloid precursor protein modulates A-beta-protein toxicity.
- Newspaper article from: Biotech Week December 10, 2003 700+ words
...NewsRx.net) -- Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity. "The amyloid beta...Neurochemistry (Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity. J Neurochem, 2003...
- Protein modulates growth factor induction of pulmonary valve endothelial cells.
- Newspaper article from: Proteomics Weekly March 10, 2003 700+ words
2003 MAR 10 - (NewsRx.com & NewsRx.net) -- A protein modulates growth factor induction of pulmonary valve endothelial cells. According to a study from the United States, "mice deficient for...
- HIC protein modulates P-TEFb-dependent HIV transcription.
- Newspaper article from: Genomics & Genetics Weekly October 31, 2003 700+ words
2003 OCT 31 - (NewsRx.com & NewsRx.net) -- The HIC protein modulates P-TEFb-dependent HIV transcription. "Positive transcription elongation factor b (P-TEFb) hyperphosphorylates the carboxy...