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Recent developments in prion immunotherapy reviewed.
2004 DEC 1 - (NewsRx.com & NewsRx.net) -- Researchers review recent developments in prion immunotherapy in the journal Current Opinion in Immunology.
According to a study from Switzerland, "Antibody-based immunotherapy may represent a realistic approach against prion diseases, given that antibodies to the cellular prion protein PrP[superscript]c have been shown to antagonize deposition of the disease-associated prion protein (termed PrP[superscript]Sc) in in vitro assays and in laboratory animals. However, induction of protective antiprion immune responses in wild-type animals is difficult because of host tolerance to the endogenous PrP[superscript]c. Several studies indicate that it might be possible to overcome tolerance to PrP[superscript]c and induce immune responses to bacterially expressed, recombinant PrP."
"However, it is much more difficult to induce antibodies capable of recognizing native cell-surface PrP[superscript]c, and there is reason to believe that the latter immune responses correlate with anti-prion protection," said Frank L. Heppner and Adriano Aguzzi at University Hospital Zurich. ...
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Source: HighBeam Research, Recent developments in prion immunotherapy reviewed.