AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Well-differentiated breast tumors have more 16q loss than poorly differentiated.
2004 NOV 4 - (NewsRx.com & NewsRx.net) -- Well-differentiated breast tumors have more 16q loss than poorly differentiated tumors.
According to a study from the Netherlands, "Loss of heterozygosity (LOH) at the long arm of chromosome 16 is a frequent genetic alteration in breast cancer. It can occur by physical loss of part of or the entire chromosomal arm, resulting in a decrease in copy number or loss followed by mitotic recombination.
"Comparative genomic hybridization (CGH) demonstrated that well-differentiated breast tumors showed significantly more physical loss of 16q than did poorly differentiated ones and that this difference was already discernable in the preinvasive stage."
"However," said A.M. Cleton-Jansen and colleagues, "polymorphic markers detected no difference in the frequency of 16q LOH between invasive tumors of different histological grade."
"Here, by combining data on LOH (n=52), fluorescence in situ hybridization (n=18) with chromosome 16-specific probes, and CGH (n=34)," scientists reported, "we show a preference in well-differentiated grade I tumors for physical loss of chromosome arm 16q, whereas in poorly differentiated grade III tumors LOH is accompanied ...
- BUTYRATE THERAPY FOR POORLY DIFFERENTIATED BREAST CANCER.
- Newspaper article from: Life Sciences & Biotechnology Update December 1, 2000 700+ words
...research program focuses on butyrate therapy for poorly differentiated breast cancer. The research is directed at providing a...tissues of these mice, and then whether human breast cancer cell line xenografts can be selectively caused...
- Deregulated EZH2 gene may be related to poorly differentiated breast carcinoma.
- Newspaper article from: Biotech Week March 10, 2004 700+ words
...differentiation and development of poorly differentiated breast cancer in humans, researchers...healthy cells. However, poorly differentiated DCIS and invasive carcinomas...positive cells in poorly differentiated DCIS were resting...
- Fluorescence In Situ Hybridization and Immunohistochemical Assays for HER-2/neu...
- Magazine article from: Archives of Pathology & Laboratory Medicine Onody, Peter Bertrand, Francoise Muzeau, Francoise Bieche, Ivan Lidereau, Rosette June 1, 2001 700+ words
...About 70% of patients with breast cancer with no lymph node involvement...dysregulation has been linked to poorly differentiated breast cancer[3] Most prognostic studies...to screen patients with breast cancer for HER-2/neu alterations...
- NEED TO KNOW: BREAST CANCER.(Interview)
- Newspaper article from: Pulse Ruckert, Linden May 10, 2007 700+ words
...celebrities `fighting' breast cancer. There is no evidence of...Most young women with breast cancer have poorly differentiated cancers that are hormone...improvement in survival from breast cancer among women under 35, with...
- Poorly differentiated carcinoma of unknown primary site: clinical usefulness of...
- Newspaper article from: Cancer Weekly December 9, 1991 700+ words
...routine evaluation of metastatic poorly differentiated carcinoma of unknown primary site...School of Medicine. Patients with poorly differentiated carcinoma of unknown primary site...immunoperoxidase staining in patients with poorly differentiated carcinoma of unknown primary site...
- p53 gene abnormality restricted to poorly differentiated endocrine carcinomas.
- Newspaper article from: Health & Medicine Week May 24, 2004 700+ words
...gene abnormality is restricted to poorly differentiated endocrine carcinomas. According...well-differentiated and (ii) poorly differentiated neoplasms," they continued...differentiation and various hormones. Poorly differentiated endocrine carcinomas lack large...
- Poorly differentiated neuroendocrine tumor of the larynx: challenging and...
- Magazine article from: Ear, Nose and Throat Journal Arroyo, Sherley Valdez Rosel, Paul Palacios, Enrique November 1, 2006 700+ words
...Among these epithelial tumors are poorly differentiated carcinoma (also called small...immunohistochemically consistent with a poorly differentiated carcinoma of neuroendocrine differentiation...common sites of metastatic spread of poorly differentiated or small-cell neuroendocrine...
- Racial, ethnic disparities persist in presentation, treatment and survival.(of...
- Magazine article from: Women's Health Weekly January 16, 2003 700+ words
...disproportionately affected by breast cancer. In one national...ethnic variations in breast cancer outcomes among women...phase fractions and poorly differentiated tumor cells. Statistically...treatment of invasive breast cancer. African American...
- Racial, ethnic disparities persist in presentation, treatment and...
- Newspaper article from: Cancer Weekly January 14, 2003 700+ words
...disproportionately affected by breast cancer. In one national...ethnic variations in breast cancer outcomes among women...phase fractions and poorly differentiated tumor cells. Statistically...treatment of invasive breast cancer. African American...
- Large study documents how p53 mutations link to high-grade breast cancer, poor...
- Magazine article from: Women's Health Weekly May 7, 2009 700+ words
...and development of breast cancer. In this part of...isolated DNA from 803 breast cancer tumor samples, and...postmenopausal women with breast cancer, the presence of...higher-grade, poorly differentiated tumors. Women with...
Source: HighBeam Research, Well-differentiated breast tumors have more 16q loss than poorly...