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The adenoviral type 5 E1A gene sensitizes breast tumors to paclitaxel.
2004 NOV 4 - (NewsRx.com & NewsRx.net) -- The adenoviral type 5 E1A gene sensitizes breast tumors to paclitaxel.
"Paclitaxel (Taxol) is a promising frontline chemotherapeutic agent for the treatment of human breast and ovarian cancers. The adenoviral type 5 E1A gene has been tested in multiple clinical trials for its anticancer activity. E1A has also been shown to sensitize paclitaxel-induced killing in E1A-expressing cells," researchers in the United States report.
"Here, we show that E1A can sensitize paclitaxel-induced apoptosis in breast cancer cells in a gene therapy setting by an orthotopic mammary tumor model. We first showed that expression of E1A enhanced in vitro paclitaxel cytotoxicity, as compared to the control cells," said Y. Liao and colleagues, University of Texas, M.D. Anderson Cancer Center.
"We then compared the therapeutic efficacy of paclitaxel between orthotopic tumor models established with vector-transfected MDA-MB-231 (231-Vect) versus 231-E1A stable cells, using tumor weight and apoptotic index (TUNEL assay) as the parameters. We found paclitaxel was more effective in shrinking tumors and inducing apoptosis in tumor models established with stable 231-E1A cells than the control 231-Vect cells.
"We also tested whether E1A could directly enhance paclitaxel-induced killing in nude mice, by using a nonviral, surface-protected cationic liposome to deliver E1A gene via the mouse tail vein," researchers wrote.
"We compared the therapeutic effects of E1A gene therapy with or without Taxol chemotherapy in the established orthotopic tumor model of animals ...
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Source: HighBeam Research, The adenoviral type 5 E1A gene sensitizes breast tumors to paclitaxel.