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Specific vitamin D receptor gene polymorphisms associated with higher risk.
2004 NOV 4 - (NewsRx.com & NewsRx.net) -- Researchers in the U.K. have identified specific vitamin D receptor gene polymorphisms that appear to be associated with breast cancer risk.
"The steroid hormone 1,25-dihydroxyvitamin D is thought to protect against breast cancer. The actions of 1,25-dihydroxyvitamin D, are mediated via the vitamin D receptor (VDR), and a number of polymorphisms in the VDR gene have been identified. These result in distinct genotypes, some of which may alter susceptibility to breast cancer.
"We have investigated whether specific VDR gene polymorphisms are associated with breast cancer risk in a United Kingdom Caucasian population," said M. Guy, K.W. Colston, and colleagues. "In a retrospective case-control study, female breast cancer patients (n=398) and control women (n=427) were recruited, and three VDR polymorphisms were determined."
The researchers reported, "The 3' VDR polymorphisms BsmI and variable-length poly(adenylate) sequence were both significantly associated with breast cancer risk; odds ratios (adjusted for age menopausal status and hormone replacement therapy usage) for bb genotype versus BB genotype = 1.92 (95% confidence interval [CI], 1.20-3.10; p
"A 5' VDR gene variant, FokI, was not associated with breast cancer risk when analyzed in isolation (p>0.05). However, FokI did modulate the increased risk associated with the MILL genotype such that possession ...
- Gene polymorphisms and diabetic nephropathy relationship needs investigation.
- Newspaper article from: Obesity, Fitness & Wellness Week July 31, 2004 700+ words
...relationship/association between gene polymorphisms and diabetic nephropathy requires...susceptibility, and studies on candidate-gene polymorphisms and their association (or lack of...possible implication of vasoactive gene polymorphisms in the development of diabetic nephropathy...
- Osteoprotegerin gene polymorphisms associate with heart disease in men.
- Newspaper article from: Obesity, Fitness & Wellness Week October 16, 2004 700+ words
...NewsRx.net) -- Osteoprotegerin gene polymorphisms associate with heart disease in men...arterial calcification. Recently, OPG gene polymorphisms have been associated with osteoporosis...In this study, we examined OPG gene polymorphisms in 468 men who had absence of coronary...
- IL-6 gene polymorphisms associated with type 2 diabetes.
- Newspaper article from: Biotech Week December 29, 2004 700+ words
...NewsRx.net) -- The interleukin-6 gene polymorphisms C-174G and A-598G are associated...diabetes. Because the impact of IL-6 gene polymorphisms on diabetes status, parameters of...Our findings confirm that immune gene polymorphisms can be considered as independent...
- Candidate gene polymorphisms may have a role in solid cancers.
- Newspaper article from: Genomics & Genetics Weekly October 15, 2004 700+ words
...NewsRx.net) -- Understanding gene polymorphisms in surgical diseases will likely...susceptibility and severity." "Gene polymorphisms, in particular single nucleotide...their findings in EJSO (Candidate gene polymorphisms in solid cancers. EJSO, 2004...
- CRP gene polymorphisms are not linked to post-angioplasty restenosis.
- Newspaper article from: World Disease Weekly December 21, 2004 700+ words
...com & NewsRx.net) -- CRP gene polymorphisms are not linked to post-angioplasty...intronic T>A C-reactive protein gene polymorphisms in a large, previously described...Atherosclerosis (C-reactive protein gene polymorphisms and the incidence of post-angioplasty...
- Transferrin gene polymorphisms linked to late-onset Alzheimer disease.
- Newspaper article from: Biotech Week November 12, 2003 700+ words
...NewsRx.net) -- Transferrin gene polymorphisms have been linked to late-onset...between the APOE epsilon4 allele and TF gene polymorphisms." Zhang and associates published...Alzheimer's disease and the transferrin gene polymorphisms in Chinese. Neurosci Lett, 2003...
- Mannose-binding lectin gene polymorphisms are associated with GDM.
- Magazine article from: Women's Health Weekly December 23, 2004 700+ words
...net) -- Mannose-binding lectin gene polymorphisms are associated with gestational diabetes...Metabolism (Mannose-binding lectin gene polymorphisms are associated with gestational diabetes...areas of Endocrinology, Genetics, Gene Polymorphisms, Women's Health, Obstetrics...
- Lumbar spine BMD associated with TNF gene polymorphisms in epidemiologic study.
- Newspaper article from: Obesity, Fitness & Wellness Week August 21, 2004 700+ words
...associated with tumor necrosis factor gene polymorphisms in Japanese women in early postmenopause...BMD) in the lumbar spine. TNF gene polymorphisms studied were the Nco I polymorphism...lumbar spine is associated with TNF gene polymorphisms in early postmenopausal Japanese...