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PC cell-derived growth factor inflames breast tumor aggression.
2004 NOV 4 - (NewsRx.com & NewsRx.net) -- PC cell-derived growth factor inflames breast tumor aggression.
According to recent research published in the journal Carcinogenesis, "metastasis is a multi-step process involved in the progression of breast cancer to a disease with poor prognosis. Growth factor and/or growth factor receptor over-expression has been reported to play an important role in this process. The 88 kDa glycoprotein PC cell-derived growth factor (PCDGF/GP88), also known as progranulin, has been shown to play a major role in breast tumorigenesis by stimulating proliferation, mediating survival and conferring resistance to tamoxifen."
"In the present paper, the metastatic potential of PCDGF/GP88 was examined in breast cancer. Using MCF-7 cells, we showed that PCDGF/GP88 over-expression stimulated anchorage-independent cell growth and accelerated cell migration through Matrigel," reported W. Tangkeangsirisin and colleagues, A&G Pharmaceuticals Inc.
"Similar results were obtained with MCF-7 cells treated exogenously with PCDGF/GP88. Furthermore, gelatin zymograph and immunoblot revealed ...
- Tamoxifen might stimulate the growth of PCDGF/GP88-positive breast cancer.
- Newspaper article from: Biotech Week April 21, 2004 700+ words
...the growth of PCDGF/GP88-positive...cell-derived growth factor, also known as...M-r 88,000 growth factor (referred to as PCDGF/GP88) overexpressed...vascular endothelial growth factor. These studies suggest that PCDGF/GP88 plays a...
- MedImmune Identifies Novel Protein Target for Cancer Therapy; Preclinical Study...
- Press release article from: PR Newswire February 23, 2004 700+ words
...levels of PC cell-derived growth factor (PCDGF) may be an early signal...entitled "PC Cell-Derived Growth Factor Expression in Prostatic...Prostatic Adenocarcinoma," PCDGF is described as a novel growth factor that stimulates cell proliferation...
- Depression of salivary epidermal growth factor by smoking.
- Magazine article from: British Medical Journal Jones, P.D.E. Hudson, N. Hawkey, C.J. February 22, 1992 700+ words
...are, however, unclear. Epidermal growth factor is a polypeptide secreted into saliva...shown that output of salivary epidermal growth factor is diminished in patients with rheumatoid...with reduced secretion of epidermal growth factor. Patients, methods, and results...
- Cancer and insulin-like growth factor-I: a potential mechanism linking the...
- Magazine article from: British Medical Journal Smith, George Davey Gunnell, David Holly, Jeff October 7, 2000 700+ words
...environment with cancer risk Insulin-like growth factor-I acts as an important mediator between...proteins. The role of insulin-like growth factor-I in promoting cancer has been investigated...associations between insulin-like growth factor-I and prostate cancer, premenopausal...
- Hepatocyte growth factor neutralization retards cutaneous wound healing.
- Newspaper article from: Angiogenesis Weekly March 28, 2003 700+ words
...amp; NewsRx.net) -- Hepatocyte growth factor neutralization retards cutaneous wound...elucidate biologic functions of hepatocyte growth factor and the c-Met receptor in cutaneous...expression and localization of hepatocyte growth factor and c-Met receptor and used a strategy...
- Insulin-like growth factor-I can be helpful towards end of life.(Brief...
- Magazine article from: British Medical Journal Bolger, Aidan Doehner, Wolfram Anker, Stefan D March 17, 2001 700+ words
...circulating concentrations of insulin-like growth factor-I to the risk of developing certain...the use of exogenous insulin-like growth factor-I by athletes, in whom the additional...apoptotic properties of insulinlike growth factor-I be should be considered in a different...
- Connective tissue growth factor may play role in formation.
- Newspaper article from: Gastroenterology Week January 27, 2003 700+ words
...United States, "connective tissue growth factor stimulates fibroblast proliferation...expression pattern of connective tissue growth factor in postoperative intra-abdominal...blotting for temporal connective tissue growth factor mRNA and protein expression, respectively...
- Growth factor predicts cancer's spread.
- Magazine article from: Science News Fackelmann, Kathy A. March 5, 1994 700+ words
...homing in on urinary concentrations of a growth factor involved in cancer's deadly spread...that a peptide called basic fibroblast growth factor could trigger the beneficial growth...p.71). The dark side of this growth factor, and others like it, is that they...
- Epidermal growth factor receptor and proliferating cell nuclear antigen in...
- Magazine article from: Neurology India Maiti, Arpan Ghosh, Keya Chatterjee, Uttara Chakrobarti, Sasanka Chatterjee, Sandip Basu, Samik October 1, 2008 700+ words
...involvement of various growth factors, growth factor receptors and proliferative markers...being studied extensively. Epidermal Growth Factor Receptor (EGFR) gene overexpression...various growth factors like Epidermal Growth factor (EGF), Platelet Derived growth ...
- Scientists at Technical University publish research in vascular endothelial...
- Newspaper article from: Angiogenesis Weekly April 24, 2009 700+ words
...biochemical properties of the transplant remain unanswered. Basic fibroblast growth factor (bFGF), insulin-like growth factor (IGF), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF)-BB have been...
Source: HighBeam Research, PC cell-derived growth factor inflames breast tumor aggression.