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In vitro, arachidonic acid release may mediate tamoxifen, raloxifene actions.
2004 NOV 4 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Tamoxifen is being used successfully to treat breast cancer. However, tamoxifen also increases the risk of developing endometrial cancer in postmenopausal women.
"Raloxifene also decreases breast cancer in women at high risk and may have a lower risk at developing cancer of the uterus."
Previous research conducted using rat liver cells has shown that tamoxifen stimulated release of arachidonic acid from these cells.
L. Levine of Brandeis University "postulated that arachidonic acid release from cells may be associated with cancer chemoprevention."
To pursue this, Levine labeled "rat liver, rat glial, human colon carcinoma, and human breast carcinoma cells . . . with [H-3] arachidonic acid. The release of the radiolabel from these cells during incubation with tamoxifen and the raloxifene analog LY117018 was measured. The prostaglandin I-2 produced during incubation of the rat liver cells with microM concentrations of tamoxifen and the raloxifene analog was quantitatively estimated."
The experiments showed "tamoxifen is about five times more effective than LY117018 at releasing arachidonic acid from all the cells tested."
"In rat liver cells only tamoxifen stimulates basal prostaglandin I-2 production and that induced by lactacystin and 12-O-tetradecanoyl-phorbol-13-acetate. LY117018, however, blocks the ...
- Carnitine hinders arachidonic acid turnover, platelet function, oxidative...
- Newspaper article from: Heart Disease Weekly March 2, 2003 700+ words
...whether carnitine interferes with arachidonic acid metabolism and platelet function...to dose dependently inhibit arachidonic acid incorporation into platelet...phospholipids and agonist-induced arachidonic acid release. "Incubation of platelets...
- Arachidonic acid inhibition of adipocyte differentiation requires PKA.
- Newspaper article from: Biotech Week March 24, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Arachidonic acid-dependent inhibition of adipocyte...the Journal of Lipid Research, "Arachidonic acid inhibits adipocyte differentiation...differentiation in the presence of arachidonic acid." "Arachidonic acid treatment led...
- Adipose tissue arachidonic acid linked to overweight status in children.
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...net) -- Adipose tissue arachidonic acid content was associated with...2%) by adipose tissue arachidonic acid content than any other n...fatty acids. Mean levels of arachidonic acid, dihomo-gamma-linolenic...
- Peptide increases arachidonic acid release and apoptosis of muscle cells.
- Newspaper article from: Proteomics Weekly January 19, 2004 700+ words
...activator peptide, PLAP, increases arachidonic acid release and apoptosis of vascular...apoptosis is accompanied by an increase in arachidonic acid release via cytoplasmic Ca[superscript...subscript]2 leading to increased arachidonic acid release can be mimicked via direct...
- P-450 Metabolites of arachidonic acid in the control of cardiovascular...
- Magazine article from: Physiological Reviews Roman, Richard J. January 1, 2002 700+ words
...Richard J. P-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function...Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome...is likely that CYP metabolites of arachidonic acid contribute to the changes in renal...
- Suntory Confirmed that Arachidonic Acid and DHA Help Improve Brain Functions.
- News wire article from: Asia Africa Intelligence Wire November 11, 2005 700+ words
...announced on November 10 that it has discovered that arachidonic acid and docosahexaenoic acid (DHA) help improve brain functions...Medical Science, the company has examined how the intake of arachidonic acid and DHA affects brain functions in the normal elderly aged...
- ABN Announces Agreement with Martek For Arachidonic Acid Applications in...
- Press release article from: Business Wire May 11, 2004 700+ words
...to 91 of Martek's patents related to the use of ARA (Arachidonic acid) in aquaculture feed products, as well as the right to...several marine and fresh water fish species. We believe that Arachidonic acid will soon be recognized as a key ingredient in many other...
- Type 2 diabetes is associated with decreased platelet-derived nitric oxide...
- Magazine article from: Heart Tretjakovs, P. Erglis, A. Dinne, I. Dabina, I. Jurka, A. Kalnins, U. May 1, 2002 700+ words
...nitrate (NO3-) ions, and the incorporation of [3H]arachidonic acid (AA) into phospholipids of platelet membranes from coronary...the ability to produce platelet-derived NO and affects arachidonic acid metabolism. This may result in higher platelet sensitivity...
- Key Arachidonic Acid (ARA) Patent Issued To Martek.
- Press release article from: Business Wire August 20, 1997 700+ words
...to the Company covering triglyceride oils made from fungal sources containing a high concentration (at least 30%) of arachidonic acid (ARA) and a low concentration of eicosapentaenoic acid (EPA). The patent also covers the production, sale, and use...
- Martek European arachidonic acid patent upheld.(Martek Biosciences Corp.)
- Newspaper article from: BIOTECH Patent News April 1, 2005 700+ words
...Bethesda, MD) announced that the Opposition Division of the European Patent Office has upheld the company's European arachidonic acid (ARA) oil patent in a form containing modified claims which are narrower than the claims originally granted. Martek...
Source: HighBeam Research, In vitro, arachidonic acid release may mediate tamoxifen, raloxifene...