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Enterococcus faecalis fsr two-component system controls biofilm development.

Women's Health Weekly

| November 04, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 NOV 4 - (NewsRx.com & NewsRx.net) -- The Enterococcus faecalis fsr two-component system was seen to control biofilm development through production of gelatinase.

According to recent research published in the Journal of Bacteriology, "Bacterial growth as a biofilm on solid surfaces is strongly associated with the development of human infections. Biofilms on native heart valves (infective endocarditis) is a life-threatening disease as a consequence of bacterial resistance to antimicrobials in such a state.

"Enterococci have emerged as a cause of endocarditis and nosocomial infections despite being normal commensals of the gastrointestinal and female genital tracts."

L.E. Hancock and colleagues at Scripps "examined the role of two-component signal transduction systems in biofilm formation by the Enterococcus faecalis V583 clinical isolate and identified the fsr regulatory locus as the sole two-component system affecting this unique mode of bacterial growth. Insertion mutations in the fsr operon affected biofilm formation on two distinct abiotic surfaces."

"Inactivation of the fsr-controlled gene gelE encoding the ...

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Source: HighBeam Research, Enterococcus faecalis fsr two-component system controls biofilm...

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