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2004 NOV 4 - (NewsRx.com & NewsRx.net) -- The Enterococcus faecalis fsr two-component system was seen to control biofilm development through production of gelatinase.
According to recent research published in the Journal of Bacteriology, "Bacterial growth as a biofilm on solid surfaces is strongly associated with the development of human infections. Biofilms on native heart valves (infective endocarditis) is a life-threatening disease as a consequence of bacterial resistance to antimicrobials in such a state.
"Enterococci have emerged as a cause of endocarditis and nosocomial infections despite being normal commensals of the gastrointestinal and female genital tracts."
L.E. Hancock and colleagues at Scripps "examined the role of two-component signal transduction systems in biofilm formation by the Enterococcus faecalis V583 clinical isolate and identified the fsr regulatory locus as the sole two-component system affecting this unique mode of bacterial growth. Insertion mutations in the fsr operon affected biofilm formation on two distinct abiotic surfaces."
"Inactivation of the fsr-controlled gene gelE encoding the ...
Source: HighBeam Research, Enterococcus faecalis fsr two-component system controls biofilm...