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Abnormal homocysteine metabolism not key factor in autoimmune disorder.
2004 NOV 4 - (NewsRx.com & NewsRx.net) -- Study results suggest abnormal homocysteine metabolism is not a key factor in the development of antiphospholipid syndrome.
"Recent studies have identified hyperhomocysteinemia as a risk factor for both recurrent pregnancy loss and thrombosis. Antiphospholipid syndrome [APS], an autoimmune disorder, is also characterized by recurrent pregnancy loss and thrombosis. Thus, our purpose was to determine if hyperhomocysteinemia is more common in patients with APS than normal fertile controls," wrote R.M. Lee, University of Utah, and colleagues.
"Plasma, sera, and whole blood were obtained from two groups of women: 22 with well-characterized antiphospholipid syndrome; and 41 healthy fertile controls. Levels of fasting homocysteine, vitamin B-6, vitamin B-12, folate, and the incidence of the C677/T mutation of the methylene tetrahydrofolate reductase genotype (C677T/MTHFR) were determined," according to the researchers' report.
Lee and colleagues found that "the proportion of individuals with hyperhomocysteinemia and fasting plasma homocysteine levels were similar in women with APS and controls. Levels ...
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Source: HighBeam Research, Abnormal homocysteine metabolism not key factor in autoimmune...