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Degree of upregulation of some antioxidant defenses differs by sex.

Women's Health Weekly

| November 04, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 NOV 4 - (NewsRx.com & NewsRx.net) -- Certain antioxidant defense activities occur at higher levels in females than males, and vice versa, study data show.

"Since oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD) and since the age-adjusted incidence of AD is higher in females than males, we examined a possible influence of gender on antioxidant metabolism in brains from male and female AD patients and age-matched controls," wrote K. Schuessel and colleagues.

"Activities of copper/zinc-dependent superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione-disulfide reductase (GR) were elevated in AD samples compared to controls," they reported.

"Upon in vitro stimulation, levels of malondialdehyde formation were significantly lower in AD samples, probably due to the increased antioxidant capacity," the researchers said.

Schuessel and associates wrote, "Overall, our results indicate that antioxidant metabolism is functionally still intact but increased in AD, implying that oxidative damage is caused rather by overproduction than by insufficient detoxification of [reactive oxygen species].

"Among AD patients, a gender-specific partial upregulation of antioxidant defense was present: activities of SOD and GPx ...

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