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Computer simulations of strategies for pertussis vaccination developed.

Vaccine Weekly

| November 03, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 NOV 3 - (NewsRx.com & NewsRx.net) -- Scientists have conducted computer simulations of five new strategies for adolescent and adult pertussis vaccination.

According to a study from the United States, "Approximately one million adult pertussis cases occur annually in the U.S., and infants still die from pertussis. Computer simulations were used to predict the impact of vaccination of children, adults, and/or adolescents, and household members of newborns (cocoon strategy). Childhood vaccination greatly reduced cases in children, but increased the incidence in adolescents and adults."

"Routine adolescent and adult vaccination had a large direct effect, whereas the cocoon strategy had a predominantly indirect effect on young infants," reported Annelies Van Rie at the University of North Carolina and Herbert W. Hethcote at the University of Iowa. "The number needed to vaccinate (NNV) to prevent a case of typical pertussis in the entire population was lowest for the adolescent strategy. The cocoon strategy had the lowest NNV to prevent a case of typical pertussis in young infants."

The investigators ...

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