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Sendai virus vaccine is safe and immunogenic in healthy adults.
2004 NOV 3 - (NewsRx.com & NewsRx.net) -- Intranasal vaccination with murine parainfluenza virus type I (Sendai virus) was safe and immunogenic in healthy human adults.
"Human parainfluenza virus-type 1 (hPIV-1) is the most common cause of pediatric laryngotracheobronchitis (croup) and results in close to 30,000 U.S. hospitalizations each year. No effective vaccine is available. We examined murine PIV-1 (Sendai virus, SeV) as a live, xenotropic vaccine for the closely related human PIV-1 in a phase 1, dose escalation study in healthy adults," scientists in the United States report.
"Intranasal Sendai virus was uniformly well-tolerated and showed evidence of immunogenicity in three of nine vaccinees despite pre-existing, cross-reactive immunity presumably induced by previous exposure to human PIV-1," stated Karen S. Slobod and collaborators at St. Jude Children's Research Hospital and the University of Tennessee in Memphis. "Results encourage future trials to evaluate the efficacy of Sendai virus in preventing human PIV-1 ...
- Sendai virus expressing RSV glycoprotein elicits immune protection.
- Newspaper article from: Respiratory Therapeutics Week August 2, 2004 700+ words
...net) -- Recombinant Sendai virus expressing the G glycoprotein...we have used the murine parainfluenza virus type I (Sendai virus [SV]) as a xenogeneic...with the related human parainfluenza virus type 1 (hPIV1), and...
- Bovine parainfluenza virus type 3 vaccine shows promise in monkeys.
- Newspaper article from: Health & Medicine Week May 31, 2004 700+ words
...amp; NewsRx.net) -- Bovine parainfluenza virus type 3 (PIV-3) vaccine shows...an intrinsic property of bovine parainfluenza virus type 3 (bPIV-3) strains. This...evaluated and compared three human parainfluenza virus type 3 (hPIV-3) vaccine candidates...
- Parainfluenza virus polymerase mutations provide varying attenuation.
- Newspaper article from: Medical Letter on the CDC & FDA April 25, 2004 700+ words
...the L polymerase protein of human parainfluenza virus type 1 yield viruses with a spectrum...polymerase of recombinant human parainfluenza virus type 1 (rHPIV1). In rHPIV1...the L polymerase protein of human parainfluenza virus type 1 yield viruses with a spectrum...
- Exposure to novel parainfluenza virus and clinical relevance in 2 bottlenose...
- Magazine article from: Emerging Infectious Diseases Venn-Watson, Stephanie Rivera, Rebecca Smith, Cynthia R. Saliki, Jeremiah T. Caseltine, Shannon St. Leger, Judy Yochem, Pam Wells, Randall S. Nollens, Hendrik March 1, 2008 700+ words
Parainfluenza virus (PIV) is a leading cause of...named Tursiops truncatus parainfluenza virus type 1 (TtPIV-1), was isolated...tentatively named Tursiops truncatus parainfluenza virus type 1 (TtPIV-1) was cultured...
- Parainfluenza virus expressing fusion protein protects against RSV.
- Newspaper article from: Biotech Business Week December 27, 2004 700+ words
...com & NewsRx.net) -- Parainfluenza virus type 3 expressing the native or...chimeric bovine/human (b/h) parainfluenza virus type 3 (PIV3) expressing the human...study in the Journal of Virology (Parainfluenza virus type 3 expressing the native or...
- Progress made in development of parainfluenza virus vaccines.
- Newspaper article from: Immunotherapy Weekly January 28, 2004 700+ words
...respiratory syncytial virus and parainfluenza virus vaccines. According to a study...respiratory syncytial virus and parainfluenza virus vaccines. Clin Infect Dis, 2003...under the major subject areas of Parainfluenza Virus Vaccine, Respiratory Syncytial...
- MedImmune Progressing with Development of Vaccine Targeting Respiratory...
- Press release article from: PR Newswire October 13, 2004 700+ words
...candidate to prevent respiratory syncytial virus (RSV) and parainfluenza virus type-3 (PIV-3) has shown a protective immune response...study published in the Journal of Virology is entitled "Parainfluenza Virus Type-3 Expressing the Native or Soluble Fusion (F...
- parainfluenza virus
- Reference information from: The Mosby Medical Encyclopedia October 1, 1996 700+ words
The Mosby Medical Encyclopedia 10-01-1996 parainfluenza virus, a virus that causes lung infections in infants and young children, and, less commonly, in adults. There are four types of...
Source: HighBeam Research, Sendai virus vaccine is safe and immunogenic in healthy adults.