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People often infected have poor immune response to Neisseria vaccine.
2004 NOV 3 - (NewsRx.com & NewsRx.net) -- Frequently infected individuals exhibit aberrant IgG2 antibody response to Neisseria meningitidis polysaccharide A after vaccination.
"In search for a possible explanation of the phenotypic heterogeneity in selective immunoglobulin IgA deficiency, we studied the IgG2 antibody response to meningococcal polysaccharide A (PSA) in IgA-deficient (IgAd) individuals after vaccination with meningococcal A + C polysaccharide vaccine. Two groups of IgAd individuals, one frequently infected and one clinically apparently healthy, as well as healthy controls, were studied. In response to meningococcal A + C polysaccharide vaccine, a significant titer increase of specific IgG2 anti-PSA was found in 71% of the control individuals, in 50% of the healthy and in 42% of the infection-prone IgAd individuals," scientists in Sweden report.
"The specific IgG2 response against meningococcal PSA was significantly lower in the infection-prone IgAd individuals compared to the controls (p
Friman and associates published their study in the Scandinavian Journal of Immunology (Aberrant IgG2 antibody response to Neisseria meningitidis polysaccharide A after vaccination in frequently infected compared to ...
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