AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
B-RAF is therapeutic target in melanoma.
2004 NOV 3 - (NewsRx.com & NewsRx.net) -- B-RAF is a therapeutic target in melanoma.
According to a study from England, "B-RAF is a serine/threonine-specific protein kinase that is mutated in approximately 70% of human melanomas. However, the role of this signalling molecule in cancer is unclear. Here, we show that ERK is constitutively activated in melanoma cells expressing oncogenic B-RAF and that this activity is required for proliferation."
"B-RAF depletion by siRNA blocks ERK activity," reported M. Karasarides and colleagues, "whereas A-RAF and C-RAF depletion do not affect ERK signalling. B-RAF depletion inhibits DNA synthesis and induces apoptosis in three melanoma cell lines and we show that the RAF inhibitor BAY43-9006 also blocks ERK activity, inhibits DNA synthesis and induces cell death in these cells."
"BAY43-9006 targets B-RAF signalling in vivo and induces a substantial growth delay in melanoma tumor xenografts," investigators said.
"Our data demonstrate that oncogenic ...
- New therapeutic target for melanoma identified.
- Newspaper article from: Pharma Business Week April 27, 2009 700+ words
...Medical College in New York by Dr. Aplin and colleagues. Mcl-1 is part of the Bcl-2 protein family, and is regulated by B-RAF proteins, which are mutated in approximately 60 percent of all human melanomas. The Bcl-2 family includes several prosurvival...
- MAPK pathway may be a potential therapeutic target in ALL.
- Newspaper article from: Biotech Week January 14, 2004 700+ words
...The MAPK pathway may be a potential therapeutic target in acute lymphocytic leukemia (ALL...pathway has emerged as a potential therapeutic target for solid tumors and leukemia...identify the MAPK pathway as a potential therapeutic target in ALL and delineate a mechanism...
- Company receives patent for key mucoregulator therapeutic target.
- Newspaper article from: Drug Week May 7, 2004 700+ words
...The hCLCA1 chloride channel is a therapeutic target and component of Genaera's second...and epithelial inflammation. This therapeutic target is potentially associated with the...as we believe hCLCA1 is a critical therapeutic target for many conditions associated with...
- Genaera Receives Patent for Key Mucoregulator Therapeutic Target; - hCLCA1...
- Press release article from: PR Newswire April 7, 2004 700+ words
...The hCLCA1 chloride channel is a therapeutic target and component of Genaera's second...and epithelial inflammation. This therapeutic target is potentially associated with the...as we believe hCLCA1 is a critical therapeutic target for many conditions associated with...
- Epstein-Barr virus latent membrane protein can be therapeutic target.
- Newspaper article from: Proteomics Weekly December 23, 2002 700+ words
...protein 2A (LMP2A) represents a novel therapeutic target, Cooper and coauthors found. The...altered by the LMP2A signalosome - a therapeutic target for Epstein-Barr virus latency...membrane protein 2A (LMP2A) may be a therapeutic target * The Syk protein tyrosine kinase...
- New therapeutic target identified for rheumatoid arthritis.
- Newspaper article from: Drug Week November 21, 2008 700+ words
...Hospital for Special Surgery have identified a potential new therapeutic target that could be used to treat inflammatory disorders, such...clinical implications, as it identifies a potential new therapeutic target in the treatment of inflammatory disorders," said Lionel...
- COX17 is a therapeutic target for the treatment of non-small cell lung cancer.
- Newspaper article from: Health & Medicine Week January 5, 2004 700+ words
...NewsRx.com & NewsRx.net) -- COX17 is a therapeutic target for the treatment of non-small cell lung cancer...study in Cancer Research (Identification of COX17 as a therapeutic target for non-small cell lung cancer. Cancer Res, 2003...
- TARTAR dimer therapeutic target for treatment of HIV-1 infection.
- Newspaper article from: AIDS Weekly July 19, 2004 700+ words
...com & NewsRx.net) -- The TARTAR dimer is a therapeutic target for the treatment of HIV-1 infection. According to...structure of the TARTAR dimer renders it an intriguing therapeutic target for the treatment of HIV-1 infection." Andersen and...
Source: HighBeam Research, B-RAF is therapeutic target in melanoma.