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<a href="http://www.accessmylibrary.com/article-1G1-123784696/antibodies-p-vivax-protein.html" title="Facts and information about Antibodies to P. vivax protein studied in malaria-exposed subjects.">Antibodies to P. vivax protein studied in malaria-exposed subjects.</a>
Antibodies to P. vivax protein studied in malaria-exposed subjects.
Vaccine Weekly
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November 03, 2004 |
COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright
2004 NOV 3 - (NewsRx.com & NewsRx.net) -- Researchers have investigated the HLA class II and antibody responses to circumsporozoite protein repeats of P. vivax in individuals naturally exposed to malaria.
According to recent research published in the journal Acta Tropica, "We studied the seroreactivity against the circumsporozoite protein (CSP) repeats of Plasmodium vivax variants in individuals living in malaria-endemic area of the Brazilian Amazon region (Candeias do Jamari - RO). The prevalence of IgG antibodies for at least one of the P. vivax CSP repeats was 49%. Among these positive individuals, 34.2% were positive for the standard repeat sequence VK210, 24% for the VK247 and 31.5% for the P. vivax-like sequence."
"HLA typing showed an association between antibody responses to the CS repeats of VK247 and the presence of HLA-DR16 and between HLA-DR7 and the absence of antibody responses to the CS repeats of VK210," reported Joseli Oliveira-Ferreira at the Instituto Oswaldo Cruz and collaborators in Brazil. "We also investigated the potential relationship between HLA-DQB1 allele profile and antibody response to the CSP repeats of P. vivax but no segregation with responding profile was evidenced. ...
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Source: HighBeam Research, Antibodies to P. vivax protein studied in malaria-exposed subjects.