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Study of influenza virus A M2 peptide conjugate vaccines conducted.
2004 NOV 3 - (NewsRx.com & NewsRx.net) -- Scientists have conducted a preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys.
"A universal influenza virus vaccine that does not require frequent updates and/or annual immunizations will offer significant advantages over current seasonal flu vaccines. The highly conserved influenza virus A M2 membrane protein has been previously suggested as a potential antigen target for such a vaccine. Here, we report systematic evaluation of M2 peptide conjugate vaccines (synthetic peptides of M2 extracellular domain conjugated to keyhole limpet hemocyanin (KLH) or Neisseria meningitidis outer membrane protein complex (OMPC)) in mice, ferrets, and rhesus monkeys," researchers in the United States report.
"The conjugate vaccines were highly immunogenic in all species tested and were able to confer both protection against lethal challenge of either HIN1 or H3N1 virus in mice and reduce viral shedding in the lower respiratory tracts of mice and ferrets," said Jiang Fan and colleagues at Merck Research Laboratories. "The protection against lethal challenge in mice could also be achieved by passive transfer of monkey sera containing high M2 antibody titers. In addition, we showed that M2 ...
- Study of influenza virus A M2 peptide conjugate vaccines conducted.
- Newspaper article from: Biotech Week November 3, 2004 700+ words
...preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets...A universal influenza virus vaccine that does...Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets...
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- Newspaper article from: Health & Medicine Week June 14, 2004 700+ words
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...responses to meningococcal group C conjugate vaccines and bacteria. "Antibody responses...evaluate antibody responses to MCPS conjugate vaccines, including either O-acetylated...that sera from mice immunized with conjugate vaccines contain antibodies that bind more...
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- Newspaper article from: Vaccine Weekly June 22, 1998 700+ words
...Streptococcal Type III Polysaccharide Conjugate Vaccines That Influence Immunogenicity and...efficacy of polysaccharide-protein conjugate vaccines are influenced by three variables...affected the immunogenicity of the conjugate, vaccines were synthesized using capsular ...
- Supplementary statement: change in administration schedule for haemophilus b...
- Newspaper article from: Morbidity and Mortality Weekly Report April 13, 1990 700+ words
...exist among different Haemophilus b conjugate vaccines [1]. However, further studies...immunogenicity of the Haemophilus b conjugate vaccines when given to children in this age...age using any of the Haemophilus b conjugate vaccines licensed for use. Prior ACIP recommendations...
