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Drug-DNA combination could offer longer-lasting, more efficient flu vaccine.
2004 NOV 3 - (NewsRx.com & NewsRx.net) -- Research from Sweden suggests that adding the drug tucaresol to plasmid DNA influenza vaccines could offer longer-lasting and more efficient protection against the influenza virus.
Annual flu epidemics continue to pose major health problems worldwide despite yearly vaccination efforts. Studies indicate protection offered by the current vaccine to be short-lived and only capable of targeting specific strains of the virus. Because influenza strains are highly variable, a vaccine with higher efficacy is necessary.
DNA vaccines differ from traditional vaccines in that they are entirely gene-based and are designed to target genes intracellularly. Researchers are actively pursuing plasmid DNA (pDNA) vaccines as a favorable new form of vaccination as studies show they are quick to generate (days or weeks vs. months or years), are cost-effective, and could offer long-term protection against various infectious diseases.
The pDNA vaccine specific to this study contains conserved genes from the flu virus, and although safer due to its lack of live viral strains, has shown to be weaker in inducing immune responses. Tucaresol, a drug that stimulates the immune system, is capable of interacting with molecules on the surface of T cells and was ...
- Influenza virus matrix protein plus ribonucleoproteins may control viral growth.
- Newspaper article from: Vaccine Weekly February 19, 2003 700+ words
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...of the ca/ts Len/17 influenza virus," researchers in the United...areas of Influenza Vaccine, Influenza Virus, Vaccine Efficacy, Vaccine...article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com &...
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Killed and live influenza virus vaccines are effective in preventing...available doses. Finally, universal influenza virus vaccines seem to be within reach...agencies and if a robust market for influenza virus vaccines against interpandemic...
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...effect of Wen-Pi-Tang extract on influenza virus infection in mice was investigated...body wt. for 8 consecutive days to influenza virus-infected mice reversed the lack...levels of uric acid and allantoin in influenza virus-infected mice were reduced by Wen...
- Natural Killer Cells May Help Protect Against New Strains of Influenza Virus.
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...NK, cells in controlling primary influenza virus infection. These findings may help...conducted on the specific H1N1 strain of influenza virus referred to as "swine flu," Drexel...time it encounters a new strain of influenza virus?" Using a mouse model of primary...
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...pigs, horses, and fowl (1). Influenza virus is known for its continuous genetic...canine) that historically do not carry influenza virus (3,4), which alerted both regulatory...to expansion of the host range of influenza virus. We report an outbreak of respiratory...
Source: HighBeam Research, Drug-DNA combination could offer longer-lasting, more efficient flu...