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Polysaccharides from Salvia officinalis are immuno-modulators.

Vaccine Weekly

| November 03, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 NOV 3 - (NewsRx.com & NewsRx.net) -- Water-soluble polysaccharides from Salvia officinalis possess immunomodulatory activity.

"A water-soluble polysaccharide complex (A) composed of galactose (17.9%), 3-O-methyl-galactose (3.0%), glucose (15.5%), mannose (8.3%), arabinose (30.4%), xylose (7.6%), fucose (2.6%), rhamnose (6.7%), and uronic acids (8.0%) has been isolated from the aerial parts of sage (Salvia officinalis) by cold water extraction," investigators in Slovakia and the Czech Republic report.

"It showed a broad molecular-mass distribution pattern (M[subscript]w (approx)2000-93 000) with a predominance of polymers with M[subscript]w

The researchers concluded, "The acidic polysaccharide fractions A[subscript]2, A[subscript]3, and A[subscript]4 exhibited the highest mitogenic and co-mitogenic activities of all fractions tested, and relatively high SI[subscript]comit/SI[subscript]mit ratios (approx)3 indicate potential adjuvant properties of these polysaccharides."

Capek and his coauthors published their study in Phytochemistry (Water-soluble polysaccharides from Salvia officinalis L. possessing immunomodulatory activity. Phytochemistry, 2004;65(13):1983-1992).

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