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HPV type 18 L1 VLP vaccine safe and immunogenic in women.
2004 NOV 3 - (NewsRx.com & NewsRx.net) -- Results from a phase I study indicated a human papillomavirus (HPV) type 18 L1 VLP vaccine was safe and immunogenic in women.
"Human papillomavirus (HPV) infection can cause genital warts and cervical cancer. HPV types 6 and 11 cause >90% of genital wart cases; HPV16 and 18 cause 70% of cervical cancers. A prophylactic HPV (types 6, 11, 16, 18) L1 virus-like particle (VLP) vaccine may substantially reduce the incidence of these lesions. This report describes the results of a phase I study of the HPV18 component of such a vaccine," scientists writing in the journal Vaccine report.
"Forty women were randomized to receive either HPV18 L1 VLP vaccine or placebo," said Kevin A. Ault at the University of Iowa and collaborators in the U.S. "Anti-HPV18 responses were measured using a competitive radioimmunoassay (cRIA). Tolerability was evaluated using vaccination report cards (VRC). The study showed that the HPV18 L1 VLP vaccine was generally well-tolerated and highly immunogenic. Peak anti-HPV18 geometric mean titers in vaccines were 60-fold greater ...
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- Magazine article from: OB GYN News Moon, Mary Ann August 1, 2003 700+ words
...contain viruslike particles from human papillomavirus types known to cause cervical...trials for VLP vaccines for human papillomavirus (HPV). An initial trial...drug companies. The HPV-16 VLP vaccine failed to induce seroconversion...
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- Press release article from: Business Wire July 18, 2007 700+ words
...Oregon. Preclinical data on its 1918 VLP vaccine, designed to protect against the highly...presented data on its novel bivalent VLP vaccine technology which creates VLP vaccines...published in September. TechnoVax's VLP vaccine technology uses a cell-based system...
- Novavax Announces Enrollment in the Second Phase II Study of its Seasonal...
- Press release article from: PR Newswire May 5, 2009 700+ words
...seasonal influenza virus-like particle (VLP) vaccine progresses with study designed to select...influenza strains showed that the trivalent VLP vaccine candidate induced robust immune responses...to the outbreak, Novavax is making a VLP vaccine candidate against the outbreak strain...
- Novavax Completes Enrollment of Its Second Phase II Seasonal Influenza VLP...
- Press release article from: PR Newswire May 15, 2009 700+ words
...placebo-controlled study is evaluating a VLP vaccine against the H3N2, H1N1, and B influenza...Phase II study evaluated a trivalent VLP vaccine against the seasonal influenza strains...injection of either a placebo or the VLP vaccine at doses of 15 mcg or 60 mcg per strain...
- Novavax and the NIH agree to evaluate a virus-like particle (VLP) vaccine...
- News wire article from: Chemical Business Newsbase June 4, 2009 700+ words
...evaluation of a virus-like particle (VLP) vaccine candidate against the novel influenza...Novavax has produced influenza A (H1N1) VLP vaccine against the strain recommended by the...Novavax believes that its influenza VLP vaccine technology could be part of the solution...
- Novavax Completes Enrollment of Its Seasonal Influenza VLP Vaccine Phase IIa...
- Press release article from: PR Newswire September 19, 2008 700+ words
Rapid Seasonal influenza VLP vaccine trial enrollment positions Company...doses of its seasonal influenza VLP vaccine. Specifically, the vaccine will...potent immune response. Novavax's VLP vaccine may be differentiated from other...
- Novavax completes enrolment of its second Phase II seasonal influenza VLP...
- News wire article from: Chemical Business Newsbase May 15, 2009 700+ words
...placebo-controlled study is evaluating a VLP vaccine against the H3N2, H1N1, and B influenza...Phase II study evaluated a trivalent VLP vaccine against the seasonal influenza strains...injection of either a placebo or the VLP vaccine at doses of 15 mcg or 60 mcg per strain...
- Novavax Reports Positive Preclinical Results for a Novel, Broadly...
- Press release article from: PR Newswire February 19, 2009 700+ words
...pandemic influenza virus-like particle (VLP) vaccine candidate that provided protection against...immunized with this broadly protective H5N1 VLP vaccine candidate. The H5N1 VLP contains three...In this study, two injections of the VLP vaccine candidate resulted in 100% survival...
- Novavax reports positive pre-clinical results for a novel, broadly...
- News wire article from: Chemical Business Newsbase February 19, 2009 700+ words
...pandemic influenza virus-like particle (VLP) vaccine candidate that provided protection against...immunized with this broadly protective H5N1 VLP vaccine candidate. The H5N1 VLP contains three...In this study, two injections of the VLP vaccine candidate resulted in 100% survival...
- Novavax completes enrolment of its seasonal influenza VLP vaccine Phase IIa...
- News wire article from: Chemical Business Newsbase September 19, 2008 700+ words
...immunogenicity of different doses of its seasonal influenza VLP vaccine. Specifically, the vaccine will be studied in about 300...they are able to induce potent immune response. Novavax's VLP vaccine may be differentiated from other influenza vaccines in several...
Source: HighBeam Research, HPV type 18 L1 VLP vaccine safe and immunogenic in women.