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Heat shock protein is cytoprotective in gastric mucosa of cirrhosis.
2004 NOV 3 - (NewsRx.com & NewsRx.net) -- Expression of a 72-kDa heat shock protein is cytoprotective in the gastric mucosa of cirrhotic rats.
Portal hypertensive gastropathy (PHG) is a clinical entity that is observed frequently in patients with liver cirrhosis. In PHG, gastric mucosa is highly susceptible to mucosal injury caused by noxious agents. Many studies, including ours, have reported that a 72-kDa heat shock protein (HSP72) has a crucial cytoprotective function in gastric mucosa. In this study, we investigated the expression and cytoprotective effect of HSP72 on gastric mucosa in portal hypertensive rats," scientists in Japan report.
"PHG was produced by bile duct ligation (BDL) or carbon tetrachloride administration in male Sprague-Dawley rats," said Daisuke Watanabe and colleagues at Akita University. "The expression of HSP72 in the gastric mucosa was evaluated by Western blotting. Induction of gastric mucosal HSP72 by 6-hour water-immersion stress was compared between cirrhotic and control rats. Also, mucosal protective abilities against hydrochloric acid (HCl; 0.6 N) following pretreatment with water-immersion stress to induce HSP72 were studied in both groups."
"Portal venous pressure was significantly higher in cirrhotic rats compared with control rats (p
The researchers concluded, "These findings suggest that HSP72 in the gastric mucosa plays a crucial role with respect to ...
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