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Ascorbate-Cu(II) protects CF-1 mice against HSV-2 encephalitis.
2004 NOV 3 - (NewsRx.com & NewsRx.net) -- Ascorbate-Cu(II) inactivated HSV-2 and protected CF-1 mice against encephalitis.
"Ascorbate is an important antioxidant. However, in the presence of transition metals such as Cu(II) or Fe(III), it also has pro-oxidant capabilities. The effect of ascorbate-Cu(II) in the in vitro infection of herpes simplex virus type 2 (HSV-2) and its protecting effect in a murine model was investigated. HSV-2 was treated with different concentrations of ascorbate in the presence of Cu(II). A group of CF-1 mice were treated with the inactivated virus and other treated with maintenance medium containing only ascorbate-Cu(II)," investigators in Mexico report.
"Weeks later, mice were challenged intranasally with infectious viruses," said Gabriel Betanzos-Cabrera at the Universidad Autonoma del Estado de Hidalgo and collaborators at the Escuela Nacional de Ciencias Biologicas. "HSV-2 was completely inactivated by 2 mM ascorbate plus 1 mM Cu(II). Ascorbate or Cu(II) alone did not inactivate the virus. Compared with the control group, 60% of the immunized animals did not show any sign of encephalitis and survived the herpes virus infection, while a 7% survival rate was observed in the control group (p=0.056)."
"We concluded that the in vitro treatment ...
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Source: HighBeam Research, Ascorbate-Cu(II) protects CF-1 mice against HSV-2 encephalitis.