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Raf kinase expression increases mortality of influenza-infected mice.
2004 NOV 3 - (NewsRx.com & NewsRx.net) -- Lung-specific expression of active Raf kinase results in increased mortality of influenza A virus-infected mice.
According to published research from Germany, "Alterations in signaling via the Raf/MEK/ERK pathway interfere with influenza A virus replication in cell culture. While virus yields are reduced in cells expressing dominant-negative Raf or ERK, virus propagation is enhanced upon expression of constitutively active Raf or MEK. To study the impact of active Raf on influenza virus propagation in vivo, we investigated transgenic mice expressing an activated mutant of c-Raf (Raf-BxB) in the main target tissue of influenza virus, the lung."
"Raf-BxB expression results in multicentric alveolar adenomas," said Veronika Olschlager at the Bundesforschungsanstalt fur Viruskrankheiten der Tiere and collaborators in Germany. "Influenza virus A infection of Raf-BxB mice results in increased disease symptoms and higher mortality rates. The immune response against viral pathogens in transgenic animals did not differ from wild-type mice as determined by the use of a pseudorabies virus (PRV) as a model for a viral infection not affecting the lung. No significant differences of influenza virus titers in the lung of Raf-BxB and wild-type mice were observed."
"However, ...
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Source: HighBeam Research, Raf kinase expression increases mortality of influenza-infected mice.