Chemotherapy after vaccination benefits glioblastoma patients.

2004 NOV 3 - (NewsRx.com & NewsRx.net) -- Chemotherapy after vaccination was beneficial in glioblastoma multiforme patients.

According to recent research published in the journal Clinical Cancer Research, "Although the development of immune-based therapies for various cancers including malignant glioma has been heralded with much hope and optimism, objective clinical improvements in most vaccinated cancer patients have not been realized. To broaden the search for vaccine-induced benefits, we examined synergy of vaccines with conventional chemotherapy. Survival and progression times were analyzed retrospectively in 25 vaccinated (13 with and 12 without subsequent chemotherapy) and 13 nonvaccinated de novo glioblastoma (GBM) patients receiving chemotherapy."

"Immune responsiveness and T-cell receptor excision circle (TREC) content within CD8+ T cells (CD8+ TRECs) was determined in vaccinated patients," said Christopher J. Wheeler and colleagues at Cedars-Sinai Medical Center. "Vaccinated patients receiving subsequent chemotherapy exhibited significantly longer times to tumor recurrence after chemotherapy relative to their own previous recurrence times, as well as significantly longer postchemotherapy recurrence times and survival relative to patients receiving isolated vaccination or chemotherapy."

"Patients exhibiting objective (>50%) tumor regression, extremely rare in de novo GBM, were also confined to the vaccine + chemotherapy group," reported Wheeler and his collaborators. "Prior tumor behavior, demographic ...