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Interaction of two botulinum subdomains needed to elicit antibodies.
2004 NOV 3 - (NewsRx.com & NewsRx.net) -- Interaction between the two subdomains of the C-terminal part of the botulinum neurotoxin A is essential for the generation of protective antibodies.
According to a study from France, "The botulinum neurotoxin A C-terminal fragment (He), which mediates the binding of the toxin to neuronal cell surface receptors, comprises two subdomains, Hc-N (amino acids 873-1095) and Hc-C (amino acids 1096-1296). In order to define the minimal fragment of He carrying protective antigenic properties, He, Hc-N and Hc-C have been produced as recombinant proteins in Escherichia coli, and have been tested for their antigenicity in mouse protection assays. He, Hc-N, and Hc-C induced similar antibody levels as shown by ELISA."
"However, a single immunization with He (10 microgram) fully protected mice challenged with 10[superscript]3 mouse lethal dose 50 of toxin, whereas Hc-N, Hc-C, or Hc-N plus Hc-C did not give any protection," reported Mahmood Tavallaie at the Institute Pasteur in Paris and collaborators in France. "Triple immunizations with Hc-N or Hc-C were necessary to induce a higher level of protection. Circular dichroism and fluorescence studies showed that the isolated subdomains were folded and stable. However, an intense near-UV dichroic signal ...
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Source: HighBeam Research, Interaction of two botulinum subdomains needed to elicit antibodies.